Pre‐pubertal diet restriction reduces reactive oxygen species and restores fertility in male WNIN/Obese rat

Summary Obesity is a multifactorial disorder associated with increased body adiposity, chronic oxidative stress which contributes to impaired fertility in males. Diet restriction and anti‐oxidant supplementations are known to protect obese subjects from oxidative stress and improves fertility. Howev...

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Published inAndrologia Vol. 50; no. 2; pp. e12849 - n/a
Main Authors Dinesh Yadav, D. M., Muralidhar, M. N., Prasad, S. M. V. K., Rajender Rao, K.
Format Journal Article
LanguageEnglish
Published Germany John Wiley & Sons, Inc 01.03.2018
Subjects
Adipose tissue
Age
Body composition
Body fat
Body weight gain
Diet
diet restriction
Fertility
Lipids
male fertility
Males
Nutrient deficiency
Obesity
Oxidation
Oxidative stress
Reactive oxygen species
Rodents
WNIN/Ob
diet restriction
male fertility
obesity
oxidative stress
WNIN/Ob
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Summary:Summary Obesity is a multifactorial disorder associated with increased body adiposity, chronic oxidative stress which contributes to impaired fertility in males. Diet restriction and anti‐oxidant supplementations are known to protect obese subjects from oxidative stress and improves fertility. However, the role of oxidative stress and the age of intervention in restoring male fertility are poorly understood. This study was aimed to assess the effect of diet restriction on fertility with respect to the age of intervention, body composition and oxidative stress using WNIN/Ob obese mutant rat strain. Unlike lean and carrier phenotypes, obese rats are hyperphagic, hyperlipaemic and infertile. Male obese rats aged for 35, 60 and 90 days were fed either ad libitum or diet restricted for 6 weeks. Upon diet restriction mean body weight, total body fat percentage, circulatory lipids and oxidative stress markers were significantly reduced and it follows the order as 35 < 60 < 90 days. Diet‐restricted males of the three age groups were allowed to mate with female carrier rats, and fertility was restored only in 35‐day group. Diet restriction in male obese WNIN/Ob rats lowered the rate of body weight gain, with reduced oxidative stress overall and fertility restoration in groups intervened at pre‐pubertal stages.
Bibliography:This work was supported by National Institute of Nutrition‐ICMR, Intramural grants No. 11‐NC02
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SourceType-Scholarly Journals-1
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ISSN:0303-4569
1439-0272
1439-0272
DOI:10.1111/and.12849