Association of Lp‐PLA2 G994T gene polymorphism with risk of ischemic stroke in Chinese population

The association between lipoprotein‐associated phospholipase A2 (Lp‐PLA2) G994T gene polymorphism and the risk of ischemic stroke is unclear. The aim of this study is to investigate the influence of Lp‐PLA2 G994T genetic variant on the pathogenesis of ischemic stroke in Chinese population. A total o...

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Published inJournal of biochemical and molecular toxicology Vol. 31; no. 12
Main Authors Ni, Jing, Gu, Hong, Hu, Wuhao, Zhou, Fang, Zhu, Xue, Wang, Ke
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.12.2017
Subjects
1-Alkyl-2-acetylglycerophosphocholine Esterase - genetics
Adult
Case-Control Studies
China
Diuretics
Female
Gene polymorphism
Genetic Association Studies
Genetic diversity
Genetic Predisposition to Disease
Genetic variance
Humans
Ischemia
ischemic stroke
Lipoproteins, LDL - blood
Lipoproteins, LDL - metabolism
Lp‐PLA2
Male
Middle Aged
Oxidation-Reduction
Pathogenesis
Patients
Phospholipase
Phospholipase A2
Polymorphism
Polymorphism, Single Nucleotide
Risk Factors
Stroke
Stroke - blood
Stroke - genetics
gene polymorphism
Lp-PLA2
ischemic stroke
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Summary:The association between lipoprotein‐associated phospholipase A2 (Lp‐PLA2) G994T gene polymorphism and the risk of ischemic stroke is unclear. The aim of this study is to investigate the influence of Lp‐PLA2 G994T genetic variant on the pathogenesis of ischemic stroke in Chinese population. A total of 348 patients with a clinical diagnosis of ischemic stroke and 260 gender‐matched control subjects under physical examination were recruited from hospitals and genotyped for G994T gene polymorphism. The results showed that there was a significant difference in the genotype distribution between the two groups and people with GT or TT genotype were associated with the higher risk of ischemic stroke even after adjusting the effects of potential confounding factors. In addition, both ischemic stroke patients and control subjects carrying T allele showed relatively lower Lp‐PLA2 activity and higher oxLDL level. Therefore, Lp‐PLA2 G994T gene polymorphism may be an independent risk factor of ischemic stroke in Chinese population.
Bibliography:Contract grant number: RY201702.
Contract grant sponsor: Jiangsu Rongjun Hospital.
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ISSN:1095-6670
1099-0461
1099-0461
DOI:10.1002/jbt.21999