Predicting inadequate treatment response in children with chronic spontaneous urticaria

• Published in: Pediatric allergy and immunology Vol. 31; no. 8; pp. 946 - 953
• Main Authors: Park, Yu‐Mi, Oh, Min‐Su, Kwon, Ji‐Won, Ebisawa, Motohiro
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.11.2020
• Subjects: allergen sensitization; Antinuclear antibodies; child; Children; chronic spontaneous urticaria; Disease control; Erythrocyte sedimentation rate; Leukocytes (eosinophilic); Medical records; Patients; Skin tests; Thyroid; treatment outcome; Urticaria; allergen sensitization; chronic spontaneous urticaria; treatment outcome; child
• ISSN: 0905-6157; 1399-3038
• DOI: 10.1111/pai.13319

Background We aimed to investigate the treatment response and associated factors for loss of control in children with chronic spontaneous urticaria (CSU). Methods A total of 240 CSU patients (aged 0‐17 years) were enrolled in a single‐center study in Korea from May 2014 to May 2019. We retrospectively reviewed the medical records and compared the duration of treatment and step of medications using the urticaria control test (UCT, range 0‐16 points). Serum total immunoglobulin levels, eosinophil count, allergic sensitization, autologous serum skin test, antinuclear antibody, thyroid function test, erythrocyte sedimentation rate, and C‐reactive protein were measured. The patients were divided into well‐controlled (sustained UCT ≥12), partly controlled (fluctuating UCT around 12), and poorly controlled (sustained UCT <12) groups. Results Of the 240 children, 150 (62.5%) achieved well‐controlled status; 74 (30.8%), partly controlled; and 16 (6.7%), poorly controlled. Longer duration (adjusted odds ratio: 1.09, 95% confidence interval: 1.05‐1.13, P < .001) and higher treatment steps (5.61, 2.82‐11.14, P < .001) for reaching the initial 12 points or more of UCT score, initial urticaria activity score (UAS) score (1.06, 1.03‐1.09, P < .001), and food sensitization (1.88, 1.03‐3.46, P = .041) were associated with inadequate treatment response. The mean duration to symptom free for 1 month without medication was 14.6 months in the well‐controlled group and 22.1 months in the partly controlled group (P = .002). Conclusion Children with CSU have a good treatment response. Longer duration and higher treatment step until the initial disease control, higher initial UAS7 score, and food sensitization can predict inadequate treatment response.