Increased early enteral zinc intake improves weight gain in hospitalised preterm infants

Aim To test the hypothesis that enteral zinc intake is associated with improved preterm infant growth during neonatal intensive care unit (NICU) hospitalisation. Methods This prospective cohort study enrolled 105 preterm infants at a tertiary referral centre. Enteral zinc intake was calculated at da...

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Bibliographic Details
Published inActa Paediatrica Vol. 108; no. 11; pp. 1978 - 1984
Main Authors Harris, Tracey, Gardner, Fumiyuki, Podany, Abigail, Kelleher, Shannon L., Doheny, Kim K.
Format Journal Article
LanguageEnglish
Published Norway Wiley Subscription Services, Inc 01.11.2019
Subjects
Birth
Breast milk
Circumferences
Head
Health risk assessment
Infant growth
Infant nutrition
Infants
Multiple regression analysis
Neonates
Neonatology
Newborn babies
Physical growth
Premature babies
Prematurity
Regression analysis
Zinc
Neonatology
Infant growth
Prematurity
Infant nutrition
Zinc
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Summary:Aim To test the hypothesis that enteral zinc intake is associated with improved preterm infant growth during neonatal intensive care unit (NICU) hospitalisation. Methods This prospective cohort study enrolled 105 preterm infants at a tertiary referral centre. Enteral zinc intake was calculated at day of life 14, and growth was measured as change in weight, length and head circumference from birth to discharge. Nonparametric tests assessed the contribution of breast milk vs formula and enteral zinc intake on weight, length and head circumference growth. Partial correlations evaluated the impact of baseline health status and caloric intake on growth. Multiple regression analysis was then completed to determine the unique contribution of zinc intake to weight gain and head circumference growth. Results Total enteral zinc intake was positively associated with weight gain (r = 0.4, p < 0.01) and head circumference growth (r = 0.3, p < 0.01) during NICU hospitalisation. Further, multiple regression analysis showed higher zinc intake is linked to weight gain during NICU hospitalisation after accounting for postmenstrual age at birth. Conclusion Increased early enteral zinc intake is linked to weight gain during NICU hospitalisation, highlighting the importance of enteral zinc intake in early infant nutrition.
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ISSN:0803-5253
1651-2227
DOI:10.1111/apa.14828