The prognostic significance of serum aspartate transaminase and gamma‐glutamyl transferase in liver deceased donors

• Published in: Transplant international Vol. 34; no. 11; pp. 2247 - 2256
• Main Authors: Capelli, Rafaela, Kitano, Yuki, Linhares, Marcelo, Da Silva, Doris, Golse, Nicolas, Karam, Vincent, Sa Cunha, Antonio, Vibert, Eric, Azoulay, Daniel, Cherqui, Daniel, Adam, René, Allard, Marc‐Antoine
• Format: Journal Article
• Language: English
• Published: Switzerland Blackwell Publishing Ltd 01.11.2021
• Subjects: Abuse; Alanine Transaminase; Alcohol abuse; Alcoholism - blood; Aspartate Aminotransferases - blood; Aspartate transaminase; deceased donor; Donors; Drug abuse; gamma-Glutamyltransferase - blood; gamma‐glutamyl transferase; Graft Survival; Grafting; Humans; Liver; Liver Transplantation; Liver transplants; Prognosis; Retrospective Studies; Risk analysis; Risk factors; Survival; Tissue Donors; Transaminase; Transplantation; deceased donor; aspartate transaminase; gamma-glutamyl transferase; liver transplantation
• ISSN: 0934-0874; 1432-2277
• DOI: 10.1111/tri.13978

The impact of aspartate transaminases (AST) and gamma‐glutamyl transferase (GGT) in serum of deceased donors on outcomes after liver transplantation (LT) is unclear. This study aimed to explore the relationship between donor highest AST value or first donor GGT value and graft survival. All consecutive patients who underwent a primary LT in a single center with available donor AST (N = 1253) and GGT value (N = 1152) were included. There was no significant association between donor AST and 90‐day graft survival. We found a moderate association between GGT and 90‐day graft survival. We found a significant interaction with a donor history of alcohol abuse (HAA). The risk of graft loss was associated with AST and GGT in donors with an HAA but remains unchanged in donors without HAA. There was no difference in graft survival according to donor AST or GGT with a cutoff ≥95th percentile (475 UI/l for AST and 170 UI/l for GGT). However, graft survival was significantly decreased when donors combined GGT ≥ 170 UI/l and HAA (61% at one year). Hepatic grafts from donors with high AST or high GGT but without alcohol history and no additional risk factors can be transplanted in low‐risk recipient. A retrospective analysis evaluating the prognostic value of donor AST and GGT in DBD liver transplantation.