Triglyceride and glucose index is a simple and easy‐to‐calculate marker associated with nonalcoholic fatty liver disease

Objective The aim of this study was to evaluate the relationship between the triglyceride and glucose (TyG) index and nonalcoholic fatty liver disease (NAFLD) using a large, population‐based cohort study database. Methods A total of 52,575 participants were enrolled from 2007 to 2013 in the Kangbuk...

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Published inObesity (Silver Spring, Md.) Vol. 30; no. 6; pp. 1279 - 1288
Main Authors Kim, Kyung‐Soo, Hong, Sangmo, Ahn, Hong‐Yup, Park, Cheol‐Young
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.06.2022
Subjects
Alcohol
Apolipoproteins
Blood pressure
Cholesterol
Creatinine
Diabetes
Exercise
Fasting
Glucose
Hepatitis
Hypertension
Insulin resistance
Liver diseases
Medical screening
Metabolism
Physical fitness
Triglycerides
Ultrasonic imaging
South Korea
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Summary:Objective The aim of this study was to evaluate the relationship between the triglyceride and glucose (TyG) index and nonalcoholic fatty liver disease (NAFLD) using a large, population‐based cohort study database. Methods A total of 52,575 participants were enrolled from 2007 to 2013 in the Kangbuk Samsung Health Study cohort. The presence of NAFLD was ascertained by ultrasonography in the absence of other known liver diseases. Results Over a median 5.1 years of follow‐up, 7,292 participants (13.87%) were diagnosed with NAFLD. In a multivariate‐adjusted model, the hazard ratio for NAFLD of the TyG index was 1.413 (95% CI: 1.349‐1.480) in the first 6 months, 1.480 (95% CI: 1.408‐1.556) in months 6 to 12, 1.427 (95% CI: 1.370‐1.485) in months 12 to 18, and 1.246 (95% CI: 1.159‐1.339) in months >18. The hazard ratios of triglycerides, glucose, fatty liver index, and homeostatic model assessment of insulin resistance for NAFLD in months >18 were 1.124 (95% CI: 1.061‐1.190), 1.037 (95% CI: 0.970‐1.109), 1.508 (95% CI: 1.417‐1.605), and 1.177 (95% CI: 1.116‐1.242), respectively. The NAFLD‐free rate decreased with increasing TyG index quartile (p < 0.001). The TyG index level from which the risk of NAFLD increased appeared to be 8.24. Conclusions This study found that the TyG index is a simple and easy‐to‐calculate marker associated with NAFLD.
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ISSN:1930-7381
1930-739X
DOI:10.1002/oby.23438