Modulating auditory selective attention by non‐invasive brain stimulation: Differential effects of transcutaneous vagal nerve stimulation and transcranial random noise stimulation

• Published in: The European journal of neuroscience Vol. 48; no. 6; pp. 2301 - 2309
• Main Authors: Rufener, Katharina S., Geyer, Ulrike, Janitzky, Kathrin, Heinze, Hans‐Jochen, Zaehle, Tino
• Format: Journal Article
• Language: English
• Published: France Wiley Subscription Services, Inc 01.09.2018
• Subjects: Adult; Attention; Attention - physiology; auditory selective attention; Cortex (frontal); Event-related potentials; Female; Frontal Lobe - physiology; Hearing; Humans; Latency; Locus coeruleus; Locus Coeruleus - physiology; Male; Noise; P300; Parietal Lobe - physiology; Reaction Time; Transcranial Direct Current Stimulation - methods; Transcutaneous Electric Nerve Stimulation; tRNS; tVNS; Vagus nerve; Vagus Nerve - physiology; Vagus Nerve Stimulation - methods; Young Adult; tVNS; auditory selective attention; P300; tRNS
• ISSN: 0953-816X; 1460-9568; 1460-9568
• DOI: 10.1111/ejn.14128

Selective attention is a basic process required to maintain goal‐directed behavior by appropriately responding to target stimuli and suppressing reactions to non‐target stimuli. It has been proposed that auditory selective attention is linked to the activity of the locus coeruleus‐norepinergic (LC‐NE) system and a large‐scale fronto‐parietal cortical network, but there is still sparse causal evidence for these assumptions. By applying transcutaneous vagal nerve stimulation (tVNS) and transcranial random noise stimulation (tRNS) over the frontal cortex, we systematically assessed the involvement of these subcortical and cortical components in the regulation of auditory selective attention. Using a single‐blinded, sham‐controlled, within‐subject design we analyzed online effects of tVNS and tRNS in 20 healthy participants during an auditory oddball paradigm. We show significant stimulation‐dependent modulations of auditory selective attention on the behavioral and electrophysiological level. Compared to sham, tVNS increased the P3 amplitude, while tRNS reduced the reaction time to target stimuli. Moreover, both techniques reduced the P3 latency. Our data provide evidence for the functional relevance of the subcortical NE system in the regulation of neural resources that allows a phasic response to incoming target stimuli. They indicate that frontal cortex structures are crucially involved in the successful evaluation of the respective information. Moreover, our results are in favor of the LC‐P3 hypothesis claiming the vital role of the NE system in auditory selective attention and in the generation of the P3. Of note, the effects of tVNS on auditory selective attention are comparable with those evoked by pharmacological interventions and invasive vagal nerve stimulation. By applying transcutaneous vagal nerve stimulation (tVNS) and transcranial random noise stimulation (tRNS) over the frontal cortex, we assessed the involvement of the locus coeruleus‐norepinergic (LC‐NE) system and the fronto‐parietal cortical network on the auditory P3. Compared to sham, tVNS increased the P3 amplitude while tRNS reduced the reaction time to target stimuli. Moreover, both techniques reduced the P3 latency. Our results are in favor of the LC‐P3 hypothesis claiming the vital role of the NE system in auditory selective attention and in the generation of the P3.