Principles of general and regulatory proteolysis by AAA+ proteases in Escherichia coli

• Published in: Research in microbiology Vol. 160; no. 9; pp. 629 - 636
• Main Authors: Schmidt, Ronny, Bukau, Bernd, Mogk, Axel
• Format: Journal Article
• Language: English
• Published: France Elsevier SAS 01.11.2009
• Subjects: AAA protein; Adenosine Triphosphatases - metabolism; Biocatalysis; Carrier Proteins - metabolism; Clp/Hsp100; Escherichia coli; Escherichia coli - enzymology; Escherichia coli - metabolism; Escherichia coli Proteins - metabolism; N-end rule; Peptide Hydrolases - metabolism; Protein quality control; Protein Stability; Proteins - metabolism; Proteolysis; Substrate Specificity; Clp/Hsp100; N-end rule; Protein quality control; AAA protein; Proteolysis

General and regulated proteolysis in bacteria is crucial for cellular homeostasis and relies on high substrate specificity of the executing AAA+ proteases. Here we summarize the various strategies that tightly control substrate degradation from both sides: the generation of accessible degrons and th...