Principles of general and regulatory proteolysis by AAA+ proteases in Escherichia coli

General and regulated proteolysis in bacteria is crucial for cellular homeostasis and relies on high substrate specificity of the executing AAA+ proteases. Here we summarize the various strategies that tightly control substrate degradation from both sides: the generation of accessible degrons and th...

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Bibliographic Details
Published inResearch in microbiology Vol. 160; no. 9; pp. 629 - 636
Main Authors Schmidt, Ronny, Bukau, Bernd, Mogk, Axel
Format Journal Article
LanguageEnglish
Published France Elsevier SAS 01.11.2009
Subjects
AAA protein
Adenosine Triphosphatases - metabolism
Biocatalysis
Carrier Proteins - metabolism
Clp/Hsp100
Escherichia coli
Escherichia coli - enzymology
Escherichia coli - metabolism
Escherichia coli Proteins - metabolism
N-end rule
Peptide Hydrolases - metabolism
Protein quality control
Protein Stability
Proteins - metabolism
Proteolysis
Substrate Specificity
Clp/Hsp100
N-end rule
Protein quality control
AAA protein
Proteolysis
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Summary:General and regulated proteolysis in bacteria is crucial for cellular homeostasis and relies on high substrate specificity of the executing AAA+ proteases. Here we summarize the various strategies that tightly control substrate degradation from both sides: the generation of accessible degrons and their specific recognition by AAA+ proteases and cognate adaptor proteins.
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ISSN:0923-2508
1769-7123
DOI:10.1016/j.resmic.2009.08.018