Principles of general and regulatory proteolysis by AAA+ proteases in Escherichia coli
General and regulated proteolysis in bacteria is crucial for cellular homeostasis and relies on high substrate specificity of the executing AAA+ proteases. Here we summarize the various strategies that tightly control substrate degradation from both sides: the generation of accessible degrons and th...
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| Published in | Research in microbiology Vol. 160; no. 9; pp. 629 - 636 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
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Elsevier SAS
01.11.2009
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| Abstract | General and regulated proteolysis in bacteria is crucial for cellular homeostasis and relies on high substrate specificity of the executing AAA+ proteases. Here we summarize the various strategies that tightly control substrate degradation from both sides: the generation of accessible degrons and their specific recognition by AAA+ proteases and cognate adaptor proteins. |
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| AbstractList | General and regulated proteolysis in bacteria is crucial for cellular homeostasis and relies on high substrate specificity of the executing AAA+ proteases. Here we summarize the various strategies that tightly control substrate degradation from both sides: the generation of accessible degrons and their specific recognition by AAA+ proteases and cognate adaptor proteins. |
| Author | Mogk, Axel Bukau, Bernd Schmidt, Ronny |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19781640$$D View this record in MEDLINE/PubMed |
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| Keywords | Clp/Hsp100 N-end rule Protein quality control AAA protein Proteolysis |
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| SubjectTerms | AAA protein Adenosine Triphosphatases - metabolism Biocatalysis Carrier Proteins - metabolism Clp/Hsp100 Escherichia coli Escherichia coli - enzymology Escherichia coli - metabolism Escherichia coli Proteins - metabolism N-end rule Peptide Hydrolases - metabolism Protein quality control Protein Stability Proteins - metabolism Proteolysis Substrate Specificity |
| Title | Principles of general and regulatory proteolysis by AAA+ proteases in Escherichia coli |
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