Comparison of the triglyceride glucose index and modified triglyceride glucose indices in assessing periodontitis in Korean adults

• Published in: Journal of periodontal research Vol. 58; no. 3; pp. 503 - 510
• Main Authors: Lee, Hyun‐Jeong, Lee, Ji‐Won, Kim, Sue, Kwon, Yu‐Jin
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.06.2023
• Subjects: Adult; Body composition; Body Mass Index; Body measurements; Glucose; Gum disease; Humans; Insulin Resistance; Metabolic syndrome; Nutrition Surveys; Periodontal diseases; Periodontitis; Periodontitis - epidemiology; Republic of Korea - epidemiology; Risk Factors; Triglycerides; Republic of Korea; glucose; triglycerides; insulin resistance; periodontitis
• ISSN: 0022-3484; 1600-0765
• DOI: 10.1111/jre.13108

Background Periodontal diseases are closely connected with insulin resistance (IR) and metabolic syndrome. The Triglyceride Glucose Index (TyG) assesses IR, and recently, a few indices combining TyG and body composition have emerged with higher IR predictive performance than TyG alone. We aimed to examine which TyG‐related parameters are most helpful in predicting the risk of periodontal disease. Methods From 2013 to 2015, data were collected through the Korean National Health and Nutrition Examination Survey. Periodontitis was defined using the Community Periodontal Index. TyG‐body mass index (BMI), TyG‐waist circumference (WC), and TyG‐waist‐to‐height ratio (WHtR) were calculated by multiplying TyG index score by BMI, WC, and WHtR, respectively. Multiple logistic regression analysis was used to calculate odds ratio (OR) and 95% confidence intervals (CI). Receiver operating characteristic curves were used to estimate areas under the curve (AUC). Results Compared to each reference quartile (Q)1, Q4 of the TyG index, TyG‐BMI, TyG‐WC, and TyG‐WHtR were significantly associated with a higher risk of periodontitis after adjusting for confounders (OR, 95% CI; 1.23, 1.01–1.49 for TyG; 1.63, 1.22–2.17 for TyG‐BMI; 1.37, 1.04–1.81 for TyG‐WC; and 1.53, 1.16–2.02 for TyG‐WHtR). The AUC and 95% CIs of TyG, TyG‐BMI, TyG‐WC, and TyG‐WHtR in predicting periodontitis were 0.609 (0.600–0.617), 0.605 (0.596–0.617), 0.629 (0.621–0.637), and 0.636 (0.628–0.644), respectively (all p < .001). Conclusions TyG, TyG‐BMI, TyG‐WC, and TyG‐WHtR appear to be significantly associated with the prevalence of periodontitis. Among the TyG and modified TyG indices, TyG‐WHtR exhibited the highest predictive performance for periodontitis.