Assessment of macrovascular endothelial function using pulse wave analysis and its association with microvascular reactivity in healthy subjects

• Published in: Skin research and technology Vol. 23; no. 3; pp. 321 - 325
• Main Authors: Ibrahim, N. N. I. N., Rasool, A. H. G.
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.08.2017
• Subjects: Adrenergic beta-2 Receptor Agonists - pharmacology; Adult; Albuterol - pharmacology; Correlation analysis; Cross-Sectional Studies; endothelial function; Endothelium, Vascular - diagnostic imaging; Endothelium, Vascular - drug effects; Endothelium, Vascular - physiopathology; Female; Females; Forearm - blood supply; Forearm - physiopathology; Humans; Hyperemia - physiopathology; Laser-Doppler Flowmetry - methods; Low density lipoprotein; macrovascular; Male; microvascular; Microvasculature; Microvessels - diagnostic imaging; Microvessels - drug effects; Microvessels - physiopathology; post occlusive forearm skin reactive hyperemia; pulse wave analysis; Pulse Wave Analysis - methods; Reactivity; Skin - blood supply; Skin - physiopathology; Smoking; Wave analysis; endothelial function; microvascular; post occlusive forearm skin reactive hyperemia; macrovascular; pulse wave analysis
• ISSN: 0909-752X; 1600-0846
• DOI: 10.1111/srt.12338

Background Pulse wave analysis (PWA) and laser Doppler fluximetry (LDF) are non‐invasive methods of assessing macrovascular endothelial function and microvascular reactivity respectively. The aim of this study was to assess the correlation between macrovascular endothelial function assessed by PWA and microvascular reactivity assessed by LDF. Method 297 healthy and non‐smoking subjects (159 females, mean age (±SD) 23.56 ± 4.54 years) underwent microvascular reactivity assessment using LDF followed by macrovascular endothelial function assessments using PWA. Results Pearson's correlation showed no correlation between macrovascular endothelial function and microvascular reactivity (r = −0.10, P = 0.12). Conclusion There was no significant correlation between macrovascular endothelial function assessed by PWA and microvascular reactivity assessed by LDF in healthy subjects.