Endogenous RNAi and adaptation to environment in C. elegans

The contributions of short RNAs to the control of repetitive elements are well documented in animals and plants. Here, the role of endogenous RNAi and AF10 homolog ZFP-1 in the adaptation of C. elegans to the environment is discussed. First, modulation of insulin signaling through regulation of tran...

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Bibliographic Details
Published inWorm (Austin, TX) Vol. 1; no. 2; pp. 129 - 133
Main Author Grishok, Alla
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.04.2012
Landes Bioscience
Subjects
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
endogenous RNAi
epigenetics
insulin signaling
Landes
lifespan
Organogenesis
oxidative stress
PDK-1
Proteins
siRNA
transcription
insulin signaling
transcription
lifespan
endogenous RNAi
siRNA
PDK-1
epigenetics
oxidative stress
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Summary:The contributions of short RNAs to the control of repetitive elements are well documented in animals and plants. Here, the role of endogenous RNAi and AF10 homolog ZFP-1 in the adaptation of C. elegans to the environment is discussed. First, modulation of insulin signaling through regulation of transcription of the PDK-1 kinase (Mansisidor et al., PLoS Genetics, 2011) is reviewed. Second, an siRNA-based natural selection model is proposed in which variation in endogenous siRNA pools between individuals is subject to natural selection similarly to DNA-based genetic variation. The value of C. elegans for the research of siRNA-based epigenetic variation and adaptation is highlighted.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2162-4046
2162-4054
2162-4054
DOI:10.4161/worm.19538