Interleukin 1 alpha genetic polymorphisms as potential biomarkers for oral health-related quality of life in Para athletes

• Published in: Special care in dentistry Vol. 41; no. 6; p. 679
• Main Authors: Von Held, Rodrigo, Castilho, Thuanny, Antunes, Lívia Azeredo Alves, Tavares, Jhenyfer da Silva, Pivetta Petinati, Maria Fernanda, Winckler, Ciro, Neto, Zair Candido Oliveira, Scariot, Rafaela, Küchler, Erika Calvano, Brancher, João Armando, Antunes, Leonardo Santos
• Format: Journal Article
• Language: English
• Published: United States 01.11.2021
• Subjects: Adolescent; Adult; Aged; Biomarkers; Cross-Sectional Studies; Dental Caries - genetics; Humans; Interleukin-1alpha - genetics; Middle Aged; Oral Health; Para-Athletes; Polymorphism, Genetic; Quality of Life; Surveys and Questionnaires; Young Adult; oral health; genetic polymorphisms; quality of life; para athletes
• ISSN: 1754-4505
• DOI: 10.1111/scd.12627

To assess the impact of dental caries on OHRQoL in Para athletes and to evaluate whether interleukin 1 alpha (IL1A) (rs17561, rs1304037), interleukin 10 (IL10) (rs1800871), and interleukin 1 receptor antagonist (IL1RN) (rs9005) genes are potential biomarkers for OHRQoL in Para athletes. A cross-sectional study consisting of 264 Para athletes (athletics, 143; powerlifting, 61; and swimming, 60) aged between 14 and 79 years was conducted. The decayed-missing-filled teeth index was used for the clinical evaluation. The Brazilian version of the Oral Health Impact Profile (OHIP-14) was used to measure the OHRQoL. Genomic DNA was extracted from the saliva. Genetic polymorphisms were analyzed by real-time polymerase chain reaction. Descriptive and bivariate analyses were performed. The overall mean OHIP-14 score observed was 6.24 (standard deviation, 7.05) and 10.03 (standard deviation, 8.11) in Para athletes with no caries experience and with caries experience, respectively (p = .002). Para athletes with the A allele in the IL1A gene (rs17561), in a dominant model, had a significantly higher risk of poor psychological discomfort than those with the other allele (p = .03). Dental caries affected the OHRQoL in Para athletes. IL1A genetic polymorphisms were the potential biomarkers for OHRQoL in Para athletes.