Pulmonary infections after renal transplantation: a prospective study from a tropical country

• Published in: Transplant international Vol. 34; no. 3; pp. 525 - 534
• Main Authors: Mangalgi, Shreepriya, Madan, Karan, Das, Chandan J., Singh, Gagandeep, Sati, Hemchandra, Yadav, Raj, Xess, Immaculata, Singh, Sarman, Bhowmik, Dipankar, Agarwal, Sanjay Kumar, Bagchi, Soumita
• Format: Journal Article
• Language: English
• Published: Switzerland Blackwell Publishing Ltd 01.03.2021
• Subjects: Adult; Algorithms; Bacterial diseases; Bacterial infections; Computed tomography; Cytomegalovirus; Drug resistance; Epidemiology; Fungi; Humans; Infections; Infectious diseases; Kidney transplantation; Kidney Transplantation - adverse effects; Mechanical ventilation; Microorganisms; Morbidity; Mortality; Nocardia Infections - diagnosis; Nocardia Infections - epidemiology; Nocardia Infections - etiology; Nocardiosis; Opportunistic Infections; Pneumonia; Prospective Studies; Public health; pulmonary infections; Radiographs; Regression analysis; renal transplantation; Transplantation; Transplants & implants; Tuberculosis; Ventilation; renal transplantation; pulmonary infections
• ISSN: 0934-0874; 1432-2277
• DOI: 10.1111/tri.13817

Summary Pulmonary infection is a leading cause of morbidity and mortality in renal transplant recipients. In a prospective study, we characterized their epidemiology in a tropical country with high infectious disease burden. Adult renal transplant recipients presenting with pulmonary infections from 2015 to 2017 were evaluated using a specific diagnostic algorithm. 102 pulmonary infections occurred in 88 patients. 32.3% infections presented in the first year, 31.4% between 1 and 5, and 36.3% beyond 5 years after transplantation. Microbiological diagnosis was established in 69.6%, and 102 microorganisms were identified. Bacterial infection (29.4%) was most common followed by tuberculosis (23.5%), fungal (20.6%), Pneumocystis jiroveci (10.8%), viral (8.8%), and nocardial (6.9%) infections. Tuberculosis(TB) and bacterial infections presented throughout the post‐transplant period, while Pneumocystis (72.7%), cytomegalovirus (87.5%) and nocardia (85.7%) predominantly presented after >12 months. Fungal infections had a bimodal presentation, between 2 and 6 months (33.3%) and after 12 months (66.7%). Four patients had multi‐drug resistant(MDR) TB. In 16.7% cases, plain radiograph was normal and infection was diagnosed by a computed tomography imaging. Mortality due to pulmonary infections was 22.7%. On multivariate Cox regression analysis, use of ATG (HR‐2.39, 95% CI: 1.20–4.78, P = 0.013), fungal infection (HR‐2.14, 95% CI: 1.19–3.84, P = 0.011) and need for mechanical ventilation (9.68, 95% CI: 1.34–69.82, P = 0.024) were significant predictors of mortality in our patients. To conclude, community‐acquired and endemic pulmonary infections predominate with no specific timeline and opportunistic infections usually present late. Nocardiosis and MDR‐TB are emerging challenges.