INHIBITORY EFFECT OF CADMIUM ON VITAMIN D STIMULATED CALCIUM TRANSPORT IN RAT DUODENUM IN VITRO

In vitro effect of cadmium on vitamin D-stimulated calcium transport in the rat was studied using the everted gut sac technique. Calcium transport was significantly inhibited by the addition of cadmium to the mucosal incubation medium. Furthermore, the kinetic analysis of in hibitory effect of cadmi...

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Published inJournal of Nutritional Science and Vitaminology Vol. 24; no. 3; pp. 237 - 242
Main Authors MORIUCHI, Sachiko, HOSOYAI, Norimasa, OTAWARA, Yoko, WUNG, Houi Ling, TSURUKI, Fukiko
Format Journal Article
LanguageEnglish
Published Japan Center for Academic Publications Japan 1978
Subjects
Animals
Cadmium - pharmacology
Calcium - metabolism
Cholecalciferol - pharmacology
Duodenum - drug effects
Duodenum - metabolism
Female
Intestinal Absorption - drug effects
Intestinal Mucosa - drug effects
Intestinal Mucosa - metabolism
Kinetics
Magnesium - pharmacology
Rats
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ISSN0301-4800
1881-7742
DOI10.3177/jnsv.24.237

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Summary:In vitro effect of cadmium on vitamin D-stimulated calcium transport in the rat was studied using the everted gut sac technique. Calcium transport was significantly inhibited by the addition of cadmium to the mucosal incubation medium. Furthermore, the kinetic analysis of in hibitory effect of cadmium on calcium transport revealed that the type of inhibition was competitive. The apparent “Km” and “Vmax” value for calcium was 1.0 mM, and 2.86 μmoles ml-1 ⋅hr-1, respectively. An apparent “Ki” for cadmium was 0.02mM
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ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.24.237