Association of single nucleotide polymorphisms in CXCR1, CXCR2 and CXCL5 with Behçet disease: a study in the Denizli province of Turkey

• Published in: Clinical and experimental dermatology Vol. 46; no. 8; pp. 1462 - 1470
• Main Authors: Arıkan, S., Atalay, A., Öztürk, O., Duygulu, Ş., Atalay, E. Ö.
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.12.2021
• Subjects: Behcet Syndrome - genetics; Behcet's syndrome; Cell activation; Chemokine CXCL5 - genetics; CXCR2 protein; Female; Gene polymorphism; Genetic factors; Genetic Predisposition to Disease; Genotyping; Haplotypes; Humans; Immune system; Leukocyte migration; Leukocytes (neutrophilic); Male; Polymorphism; Polymorphism, Single Nucleotide; Receptors, Interleukin-8A - genetics; Receptors, Interleukin-8B - genetics; Single-nucleotide polymorphism; Transcription activation; Turkey; Vein & artery diseases; Turkey
• ISSN: 0307-6938; 1365-2230
• DOI: 10.1111/ced.14766

Summary Background Behçet disease (BD) is associated with the immune system, especially neutrophilic activity. The CXCR1, CXCR2 and CXCL5 genes mediate the activation and migration of neutrophils. Aim To investigate CXCR1, CXCR2 and CXCL5 single nucleotide polymorphisms (SNPs) and examine their association with BD. Methods We studied polymorphic sites in CXCR1 (four sites: rs16858811, rs9282752, rs16858809 and rs16858808), CXCR2 (three sites: rs2230054, rs1126579 and rs1126580) and CXCL5 (one site: rs352046) in 87 patients with BD and 111 healthy controls (HCs), using a PCR restriction‐fragment length polymorphism‐based approach for genotyping. Results We found that the CXCR2 rs2230054 TT genotype and the CXCL5 rs352046 polymorphism might be possible genetic factors responsible for BD. We did not find any association between the development of BD and any of the four CXCR1 polymorphisms or the other two CXCR2 SNPs. In addition, our haplotype analysis results indicated that the haplotypes of the CXCR2 and CXCR1–CXCR2 polymorphic loci were different between the BD and HC groups. Conclusion Our study suggests that polymorphisms of CXCR1, CXCR2 and CXCL5 may affect susceptibility to BD and increase the risk of developing the disease. These loci need to be studied in larger groups of patients from different geographical areas around the world in order to clarify the genetic background for BD pathogenesis.