Optical coherence tomographic (OCT) evaluation of intraoral non‐ablative erbium: YAG laser (SMOOTH mode) in rejuvenation of nasolabial folds; A prospective randomized split face comparative pilot study

• Published in: Skin research and technology Vol. 26; no. 3; pp. 405 - 412
• Main Authors: Moftah, Nayera, Samy, Nevien, Allam, Riham S. H. M., El Tagy, Shaza A. H., Abdelghani, Rania
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2020
• Subjects: Ablation; Adult; Comparative studies; Cosmetic Techniques; Dermis - pathology; Dermis - radiation effects; Egypt - epidemiology; Epidermis - pathology; Epidermis - radiation effects; Er: YAG laser; Erbium; Female; Humans; Lasers; Lasers, Solid-State - adverse effects; Lasers, Solid-State - therapeutic use; Middle Aged; Nasolabial Fold - pathology; Nasolabial Fold - radiation effects; nasolabial folds; optical coherence tomography; Patient Satisfaction; Pilot Projects; Prospective Studies; Randomization; Rejuvenation; Safety; Semiconductor lasers; Side effects; Skin Aging - radiation effects; Thickness; Tomography, Optical Coherence - methods; Treatment Outcome; YAG lasers; Egypt; Er: YAG laser; nasolabial folds; rejuvenation; optical coherence tomography
• ISSN: 0909-752X; 1600-0846
• DOI: 10.1111/srt.12816

Background There are both few non‐comparative studies investigating the efficacy of intraoral Er: YAG laser (SMOOTH mode) in rejuvenating nasolabial folds (NLFs) and lack of valid and objective wrinkles scales. In this prospective randomized split face comparative pilot study, we investigated the safety and efficacy of intraoral Er: YAG laser (SMOOTH MODE) compared with extraoral approach in rejuvenating NLFs using OCT as an objective evaluating tool. Materials and Methods Twenty adult women with notable NLFs were randomized in this study. The patients received 5 monthly sessions of Er: YAG laser (SMOOTH mode) using intraoral approach on one side and extraoral approach on the other side. Outcome was evaluated 2 weeks and 4 months post‐treatment by Global Aesthetic Improvement Scale (GAIS), OCT, and patients’ satisfaction. Side effects were also evaluated. Results Intraoral sides had significant increase in OCT evaluated dermal thickness at 4 months post‐treatment (P = .03) without side effects compared with extraoral sides. Extraoral approach had significantly higher patients’ satisfaction compared with intraoral approach at 2 weeks and 4 months post‐treatment (P = .03, .02, respectively). Insignificant differences between both approaches were found regarding GAIS scoring, OCT evaluated epidermal thickness at 2 weeks and 4 months post‐treatment, and OCT evaluated dermal thickness at 2 weeks post‐treatment (P < .05). Conclusion Intraoral Er: YAG laser (SMOOTH mode) is safer and more effective than extraoral approach in rejuvenating NLFs. OCT is a promising objective tool for evaluating facial wrinkles. Further studies are still needed.