Resolution of acenocoumarol‐associated calciphylaxis with drug withdrawal

Calciphylaxis is a syndrome of cutaneous ischaemic necrosis and ulceration due to arteriolar calcification with subsequent thrombosis, which rarely presents in patients without terminal kidney disease. Recently, several reports of coumarins‐associated calciphylaxis have stressed the relevance of ant...

Full description

Saved in:
Bibliographic Details
Published inAustralasian journal of dermatology Vol. 60; no. 3; pp. e223 - e226
Main Authors Suárez‐Peñaranda, José‐Manuel, Minasyan, Anna, Sainz‐Gaspar, Laura, Sánchez‐Aguilar, María‐Dolores
Format Journal Article
LanguageEnglish
Published Australia Wiley Subscription Services, Inc 01.08.2019
Subjects
Acenocoumarol - adverse effects
Aged
Aged, 80 and over
Anticoagulants
Anticoagulants - adverse effects
Atrial Fibrillation - drug therapy
Biopsy
Calcification
Calciphylaxis
Calciphylaxis - chemically induced
Deprescriptions
Drug withdrawal
Female
Fibrillation
Humans
Kidney diseases
Middle Aged
Risk factors
skin biopsy
Thrombosis
calciphylaxis
skin biopsy
acenocoumarol adverse effects
Online AccessGet full text

Cover

More Information
Summary:Calciphylaxis is a syndrome of cutaneous ischaemic necrosis and ulceration due to arteriolar calcification with subsequent thrombosis, which rarely presents in patients without terminal kidney disease. Recently, several reports of coumarins‐associated calciphylaxis have stressed the relevance of anticoagulant therapy as an important risk factor for the development of this condition. We report five cases of acenocoumarol‐associated, biopsy‐proven calciphylaxis in women aged between 64 and 92 years. The drug had been prescribed for atrial fibrillation and was taken without interruption from 14 to 224 months. Lesions were present for months in all cases and were resistant to multiple therapeutic options, but they resolved only with simple wound care measures 6–14 months after changing the anticoagulant therapy.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Case Study-2
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:0004-8380
1440-0960
1440-0960
DOI:10.1111/ajd.13006