Advanced glycation end products and their receptors did not show any association with body mass parameters in metabolically healthy adolescents
Aim We determined the relationship between circulating advanced glycation end products (AGEs), AGE receptors and homeostatic model assessment for insulin resistance (HOMA‐IR) in metabolically healthy obese and normal weight adolescents. Methods In 2015, we recruited 80 normal weight adolescents and...
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Published in | Acta Paediatrica Vol. 107; no. 12; pp. 2146 - 2151 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Norway
Wiley Subscription Services, Inc
01.12.2018
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Subjects | |
Online Access | Get full text |
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Summary: | Aim
We determined the relationship between circulating advanced glycation end products (AGEs), AGE receptors and homeostatic model assessment for insulin resistance (HOMA‐IR) in metabolically healthy obese and normal weight adolescents.
Methods
In 2015, we recruited 80 normal weight adolescents and 80 with obesity from schools Leon city, Mexico, and put them into metabolically healthy (HOMA‐IR <3.0) and unhealthy (HOMA‐IR >3.0) groups. We measured their body mass index (BMI) and carried out detailed blood analyses.
Results
We found a higher triglycerides, triglycerides/high‐density lipoproteins cholesterol (TG/HDL‐C) index, HOMA‐IR, tumour necrosis factor alpha (TNF‐α) and interleukin‐6 (IL‐6) in the metabolically healthy group and found correlations between HOMA‐IR with BMI, the TG/HDL‐C index and IL‐6 and the TG/HDL‐C index and BMI and (TNF‐α). There was no correlation between markers of obesity and circulating N‐carboxymethyl‐lysine (CML) or soluble receptor for advanced glycation end products (sRAGE). Some unhealthy adolescents had higher CML (15.5 ± 2.7 U/mL, p < 0.028) and sRAGE (3123 ± 1364 pg/mL, p < 0.001) than the healthy group.
Conclusion
HOMA‐IR and the TG/HDL‐C index were associated with BMI and inflammation markers. CML and sRAGE were not associated with obesity or inflammation. These parameters were higher in unhealthy obese adolescents. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0803-5253 1651-2227 |
DOI: | 10.1111/apa.14426 |