Non-coding RNAs in diseases with a focus on osteoarthritis

Osteoarthritis (OA) is a frequent musculoskeletal disorder affecting millions of people worldwide. Despite advances in understanding the pathogenesis of OA, prognostic biomarkers or effective targeted treatment are not currently available. Research on epigenetic factors has yielded some new insights...

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Bibliographic Details
Published inWiley interdisciplinary reviews. RNA Vol. 14; no. 3; p. e1756
Main Authors Pekáčová, Aneta, Baloun, Jiří, Švec, Xiao, Šenolt, Ladislav
Format Journal Article
LanguageEnglish
Published United States 01.05.2023
Subjects
Humans
MicroRNAs - genetics
Osteoarthritis - genetics
Piwi-Interacting RNA
RNA, Circular
RNA, Long Noncoding - genetics
epigenetic factors
non-coding RNA
biomarker
osteoarthritis
targeted treatment
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Summary:Osteoarthritis (OA) is a frequent musculoskeletal disorder affecting millions of people worldwide. Despite advances in understanding the pathogenesis of OA, prognostic biomarkers or effective targeted treatment are not currently available. Research on epigenetic factors has yielded some new insights as new technologies for their detection continue to emerge. In this context, non-coding RNAs, including microRNAs, long non-coding RNAs, circular RNAs, piwi-interacting RNAs, and small nucleolar RNAs, regulate intracellular signaling pathways and biological processes that have a crucial role in the development of several diseases. In this review, we present current knowledge on the role of epigenetic factors with a focus on non-coding RNAs in the development, prediction and treatment of OA. This article is categorized under: RNA in Disease and Development > RNA in Disease.
ISSN:1757-7012
DOI:10.1002/wrna.1756