Trimethylamine N‐oxide as a risk marker for ischemic stroke in patients with atrial fibrillation

Trimethylamine N‐oxide (TMAO) is an independent risk factor of cardiovascular disease. Our objective was to explore the relation between TMAO and ischemic stroke (IS) in patients with atrial fibrillation (AF). A total of 68 patients with AF with IS and 111 ones without IS were enrolled. The plasma l...

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Published inJournal of biochemical and molecular toxicology Vol. 33; no. 2; pp. e22246 - n/a
Main Authors Liang, Zhaoguang, Dong, Zengxiang, Guo, Meihua, Shen, Zhaoqian, Yin, Dechun, Hu, Shuang, Hai, Xin
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.02.2019
Subjects
Aged
atrial fibrillation (AF)
Atrial Fibrillation - blood
Atrial Fibrillation - complications
Biomarkers - blood
Brain Ischemia - blood
Brain Ischemia - etiology
Cardiac arrhythmia
Cardiovascular diseases
Confidence intervals
Female
Fibrillation
Health risks
Humans
Ischemia
ischemic stroke (IS)
Male
Methylamines - blood
Middle Aged
Patients
Plasma levels
Regression analysis
Risk analysis
Risk Factors
Statistical analysis
Stroke
Stroke - blood
Stroke - etiology
Trimethylamine
trimethylamine N‐oxide (TMAO)
atrial fibrillation (AF)
trimethylamine N-oxide (TMAO)
ischemic stroke (IS)
risk factors
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Summary:Trimethylamine N‐oxide (TMAO) is an independent risk factor of cardiovascular disease. Our objective was to explore the relation between TMAO and ischemic stroke (IS) in patients with atrial fibrillation (AF). A total of 68 patients with AF with IS and 111 ones without IS were enrolled. The plasma levels of TMAO remarkably increased in IS‐AF patients (8.25 ± 1.58 µM) compared with patients with AF (2.22 ± 0.09 µM, P < 0.01). The receiver operating characteristic analysis revealed that the best cutoff value of TMAO to predict IS in patients with AF was 3.53 µM with 75.0% sensitivity and 92.8% specificity (area under the curve: 0.917, 95% confidence intervals: 0.877‐0.957). Univariate and multivariate logistic regression analysis showed that TMAO was an independent predictor in IS. The level of TMAO was correlated with the CHA2DS2‐VASc score. In conclusion, TMAO was an independent predictor of IS, which could potentially refine stroke stratification in patients with AF.
Bibliography:Zhaoguang Liang and Zengxiang Dong have contributed equally to this study.
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.22246