Isolated Pericardial Effusion and Transient Abnormal Myelopoiesis in a Fetus with Down's Syndrome
Isolated pericardial effusion was detected in a fetus at 34 weeks of gestation. A male infant weighing 2,044 g was born by cesarean section because of a non‐assuring fetal heart rate pattern at 35 weeks of gestation. Transient leukocytosis (36,100/μl) with 49% blast cells was seen in this neonate. T...
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Published in | The journal of obstetrics and gynaecology research Vol. 26; no. 4; pp. 303 - 306 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.08.2000
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Subjects | |
Online Access | Get full text |
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Summary: | Isolated pericardial effusion was detected in a fetus at 34 weeks of gestation. A male infant weighing 2,044 g was born by cesarean section because of a non‐assuring fetal heart rate pattern at 35 weeks of gestation. Transient leukocytosis (36,100/μl) with 49% blast cells was seen in this neonate. The infant's karyotype was 47, XY + 21. The pericardial effusion disappeared after treatment with prednisolone at a dose of 2 mg/kg/day. Hypothyroidism was subsequently found. Thus, the subject patient with Down's syndrome developed isolated pericardial effusion, transient abnormal myelopoiesis (TAM), and hypothyroidism. Because more than 20% of the infants with TAM and Down's syndrome develop acute nonlymphocytic leukemia in early childhood, he is being closely observed. |
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Bibliography: | istex:D99656869A23C2D55FC5A796DC79258BFE8943CB ark:/67375/WNG-S0H62M0D-R ArticleID:JOG1326 ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 |
ISSN: | 1341-8076 1447-0756 |
DOI: | 10.1111/j.1447-0756.2000.tb01326.x |