Immunohistochemistry in screening for heritable colorectal cancer: what to do with an abnormal result

Recent developments in our understanding of molecular genetics have transformed screening and diagnostic practices for Lynch syndrome. The current standard involves universal tumour analysis of resected colorectal cancer (and ideally polypectomy) specimens using immunohistochemistry and molecular te...

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Published inANZ journal of surgery Vol. 90; no. 5; pp. 702 - 707
Main Authors Paredes, Steven R., Chan, Charles, Rickard, Matthew J. F. X.
Format Journal Article
LanguageEnglish
Published Melbourne John Wiley & Sons Australia, Ltd 01.05.2020
Blackwell Publishing Ltd
Subjects
Cancer
cancer screening
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - genetics
Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis
Colorectal Neoplasms, Hereditary Nonpolyposis - genetics
colorectal surgery
Diagnostic systems
Early Detection of Cancer
Genetic disorders
Genetic Testing
Genetics
hereditary cancer
Humans
Immunohistochemistry
Lynch syndrome
Mass Screening
Pathogenesis
Tumors
colorectal surgery
hereditary cancer
cancer screening
colorectal cancer
immunohistochemistry
Lynch syndrome
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Summary:Recent developments in our understanding of molecular genetics have transformed screening and diagnostic practices for Lynch syndrome. The current standard involves universal tumour analysis of resected colorectal cancer (and ideally polypectomy) specimens using immunohistochemistry and molecular techniques. Patients with abnormal immunohistochemical findings are subsequently referred for definitive mutational testing. This review relates the molecular pathogenesis of Lynch syndrome to current immunohistochemistry‐based screening strategies and discusses the interpretation and clinical implications of screening results. Recent developments in our understanding of molecular genetics have transformed screening and diagnostic practices for Lynch syndrome. The current standard involves universal tumour analysis of resected colorectal cancer (and ideally polypectomy) specimens using immunohistochemistry and molecular techniques. This review relates the molecular pathogenesis of Lynch syndrome to current immunohistochemistry‐based screening strategies and discusses the interpretation and clinical implications of screening results.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1445-1433
1445-2197
DOI:10.1111/ans.15586