Role of sentinel lymph node biopsy as a staging procedure in patients with melanoma: A critical appraisal

Worldwide, sentinel node (SN) biopsy for accurate staging is now part of the standard work‐up of patients with melanomas ≥1.0 mm Breslow thickness, as it is for staging patients with breast cancer. Nuclear medicine imaging and surgical techniques have evolved to such a degree that a SN can be identi...

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Bibliographic Details
Published inAustralasian journal of dermatology Vol. 58; no. 4; pp. 268 - 273
Main Authors Nieweg, Omgo E, Cooper, Alan, Thompson, John F
Format Journal Article
LanguageEnglish
Published Australia Wiley Subscription Services, Inc 01.11.2017
Subjects
Biopsy
Breast cancer
Humans
Lymph nodes
Lymphatic Metastasis
Melanoma
Melanoma - secondary
Melanoma - therapy
metastasis
Neoplasm Staging
Nuclear medicine
outcome
prognosis
Randomized Controlled Trials as Topic
review
Risk Assessment
Sensitivity and Specificity
Sentinel Lymph Node - diagnostic imaging
Sentinel Lymph Node - pathology
sentinel lymph node biopsy
Sentinel Lymph Node Biopsy - adverse effects
Skin Neoplasms - pathology
Skin Neoplasms - therapy
survival
Survival Rate
sentinel lymph node biopsy
metastasis
review
survival
melanoma
prognosis
outcome
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Summary:Worldwide, sentinel node (SN) biopsy for accurate staging is now part of the standard work‐up of patients with melanomas ≥1.0 mm Breslow thickness, as it is for staging patients with breast cancer. Nuclear medicine imaging and surgical techniques have evolved to such a degree that a SN can be identified and removed in virtually every patient. Nevertheless, some opposition to a routine SN biopsy remains, perhaps due to a failure to appreciate the serious implications of incomplete or inaccurate staging. Guided by a critical appraisal of the available evidence, this review elucidates the definition of an SN, discusses the sensitivity and specificity of the information it provides, emphasises that it is a minor staging procedure that can lead to improved survival when followed by appropriate therapy, and explains the necessarily unconventional and complex design of the only randomised trial that addresses this subject. It also describes other benefits and risks of an SN biopsy and outlines its role in current melanoma management.
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ISSN:0004-8380
1440-0960
1440-0960
DOI:10.1111/ajd.12655