Topical cidofovir for the treatment of recalcitrant viral warts and molluscum contagiosum in Jacobsen syndrome

Jacobsen syndrome is caused by a terminal deletion on the long arm of chromosome 11 and can be associated with immunodeficiency. Patients with Jacobsen syndrome can be predisposed to cutaneous viral infections that are difficult to treat. We report successful use of topical 1% cidofovir as treatment...

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Published inPediatric dermatology Vol. 37; no. 6; pp. 1191 - 1192
Main Authors Alsaleemi, Ali, O’Connor, Cathal, Irvine, Alan D., Leahy, Timothy Ronan
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.11.2020
Subjects
Antiviral drugs
Chromosome 11
Chromosome deletion
Cidofovir
Dermatology
Humans
Immunodeficiency
Jacobsen Distal 11q Deletion Syndrome
Molluscum contagiosum
Molluscum Contagiosum - drug therapy
Papillomaviridae
Pediatrics
Skin diseases
therapy‐topical
Viral infections
Warts
Warts - drug therapy
therapy-topical
warts
immunodeficiency
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Summary:Jacobsen syndrome is caused by a terminal deletion on the long arm of chromosome 11 and can be associated with immunodeficiency. Patients with Jacobsen syndrome can be predisposed to cutaneous viral infections that are difficult to treat. We report successful use of topical 1% cidofovir as treatment of recalcitrant verruca vulgaris in one patient and molluscum contagiosum in another patient with Jacobsen syndrome. Topical cidofovir appears to be a good treatment option in this cohort and should be considered early for treatment‐resistant cutaneous viral infections.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0736-8046
1525-1470
DOI:10.1111/pde.14355