Incidence of Ankylosing Spondylitis Among Male and Female United States Army Personnel
Objective Incidence rates of ankylosing spondylitis (AS) among males versus females are poorly understood. Results of prior research have been mixed, including findings of a 3:1 incidence ratio for males versus females, but with increasing AS rates among females. The objective was to estimate the in...
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Published in | Arthritis care & research (2010) Vol. 75; no. 2; pp. 332 - 339 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Boston, USA
Wiley Periodicals, Inc
01.02.2023
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Objective
Incidence rates of ankylosing spondylitis (AS) among males versus females are poorly understood. Results of prior research have been mixed, including findings of a 3:1 incidence ratio for males versus females, but with increasing AS rates among females. The objective was to estimate the incidence of AS among members of the US military.
Methods
We estimated the incidence of AS in a retrospective cohort study of diverse, working‐age US military service members during March 2014 to June 2017 (n = 728,556) who underwent clinical practice guideline–directed screening for chronic back pain. Incident AS cases were identified using diagnostic codes from electronic medical and administrative records.
Results
In contrast to some prior studies, AS incidence was similar among males and females (incidence rate ratio 1.16, P = 0.23; adjusted odds ratio [OR] 0.79 [95% confidence interval (95% CI) 0.61–1.02]; P = 0.072). AS rates increased approximately monotonically with age. Consistent with prior research, the AS incidence rate was greater in the White population than in the Black population (adjusted OR 1.39 [95% CI 1.01–1.66]; P = 0.04).
Conclusion
In this study population, the incidence of AS was similar for the sexes. Previous observations of male predominance have typically been derived from clinic populations that are less representative of the US race/ethnicity distribution and based on disease ascertainment tools that may have identified subjects later in their disease course. Our study population also differed in being subject to organized screenings for musculoskeletal symptoms. Our findings suggest that sex may not predict AS incidence in the US population. |
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Bibliography: | https://onlinelibrary.wiley.com/action/downloadSupplement?doi=10.1002%2Facr.24774&file=acr24774‐sup‐0001‐Disclosureform.pdf Supported by The Spondylitis Association of America. This article was produced by the authors and does not represent the position of the US Army, the US Department of Defense, or the US federal government. . Author disclosures are available at ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2151-464X 2151-4658 |
DOI: | 10.1002/acr.24774 |