Combining non‐invasive brain stimulation with functional magnetic resonance imaging to investigate the neural substrates of cognitive aging

• Published in: Journal of neuroscience research Vol. 100; no. 5; pp. 1159 - 1170
• Main Authors: Abellaneda‐Pérez, Kilian, Vaqué‐Alcázar, Lídia, Solé‐Padullés, Cristina, Bartrés‐Faz, David
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2022
• Subjects: Adults; Aging; Brain; Brain - diagnostic imaging; Brain - physiology; Brain mapping; Cognitive ability; Cognitive Aging; Functional magnetic resonance imaging; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Mental health; Nervous system; Neural networks; Neural plasticity; Neuroimaging; Neuronal Plasticity; non‐invasive brain stimulation; Older people; repetitive transcranial magnetic stimulation; Resonance; Stimulation; Substrates; transcranial direct current stimulation; Transcranial Magnetic Stimulation - methods; functional magnetic resonance imaging; non-invasive brain stimulation; transcranial direct current stimulation; cognitive aging; repetitive transcranial magnetic stimulation
• ISSN: 0360-4012; 1097-4547
• DOI: 10.1002/jnr.24514

As aging population is increasing, new methodologies to apprehend and enhance the mechanisms related to optimal brain function in advancing age become urgent. This review describes how the combined use of non‐invasive brain stimulation (NIBS) with functional magnetic resonance imaging (fMRI) provides novel experimental data on the putative neurophysiological mechanisms underlying inter‐individual differences in cognitive status among older adults, also further illuminating our understanding of theoretical models proposed within the cognitive neuroscience of aging literature. In addition, it explores published evidence of how this combined procedure entails the capacity to modify the activity and connectivity of specific brain networks in older adults, potentially leading to improvements in cognitive function and other measures reflecting mental health status. Although additional research is needed, combining NIBS with fMRI might provide innovative understanding of how fundamental brain plasticity mechanisms operate in advancing age, a knowledge that may be eventually used to refine more individually tailored approaches to promote brain health in aged populations.