The correlation between dynamic functional architecture and response to electroconvulsive therapy combined with antipsychotics in schizophrenia

• Published in: The European journal of neuroscience Vol. 55; no. 8; pp. 2024 - 2036
• Main Authors: Gong, Jie, Cui, Long‐Biao, Zhao, Ying‐Song, Liu, Zhao‐Wen, Yang, Xue‐Juan, Xi, Yi‐Bin, Liu, Lin, Liu, Peng, Sun, Jin‐Bo, Zhao, Shu‐Wan, Liu, Xiao‐Fan, Jia, Jie, Li, Ping, Yin, Hong, Qin, Wei
• Format: Journal Article
• Language: English
• Published: France Wiley Subscription Services, Inc 01.04.2022
• Subjects: Antipsychotic Agents - therapeutic use; Antipsychotics; Electroconvulsive therapy; Electroconvulsive Therapy - methods; Functional magnetic resonance imaging; Humans; Magnetic Resonance Imaging - methods; Mental disorders; Patients; Schizophrenia; Schizophrenia - drug therapy; Schizophrenia - therapy; Temporal gyrus; Temporal Lobe; temporal variability; temporal variability; electroconvulsive therapy; schizophrenia
• ISSN: 0953-816X; 1460-9568; 1460-9568
• DOI: 10.1111/ejn.15664

Attempts to determine why some patients respond to electroconvulsive therapy (ECT) are valuable in schizophrenia. Schizophrenia is associated with aberrant dynamic functional architecture, which might impact the efficacy of ECT. We aimed to explore the relationship between pre‐treatment temporal variability and ECT acute efficacy. Forty‐eight patients with schizophrenia and 30 healthy controls underwent functional magnetic resonance imaging to examine whether patterns of temporary variability of functional architecture differ between high responders (HR) and low responders (LR) at baseline. Compared with LR, HR exhibited significantly abnormal temporal variability in right inferior front gyrus (IFGtriang.R), left temporal pole (TPOsup.L) and right middle temporal gyrus (MTG.R). In the pooled patient group, ∆PANSS was correlated with the temporal variability of these regions. Patients with schizophrenia with a distinct dynamic functional architecture appear to reveal differential response to ECT. Our findings provide not only an understanding of the neural functional architecture patterns that are found in schizophrenia but also the possibility of using these measures as moderators for ECT selection. Compared with low responders, high responders exhibited significantly abnormal temporal variability in right inferior front gyrus, left temporal pole and right middle temporal gyrus. Patients with schizophrenia with a distinct dynamic functional architecture appear to reveal differential response to electroconvulsive therapy.