Emerging roles of angiopoietin‐like proteins in inflammation: Mechanisms and potential as pharmacological targets

• Published in: Journal of cellular physiology Vol. 237; no. 1; pp. 98 - 117
• Main Authors: Yang, Jing, Song, Qiu‐yi, Niu, Shu‐xuan, Chen, Hui‐jing, Petersen, Robert B., Zhang, Yu, Huang, Kun
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2022
• Subjects: Angiogenesis; Angiopoietin; Angiopoietin-like Proteins - genetics; Angiopoietin-like Proteins - metabolism; Angiopoietins - metabolism; ANGPTLs; Biomarkers; Cardiovascular diseases; drug development; Glycoproteins; Humans; Hypertriglyceridemia; Inflammation; Inflammation - drug therapy; Inflammatory diseases; Inflammatory response; integrin; Lipid Metabolism; Lipids; Metabolism; Neovascularization, Pathologic - drug therapy; oligomerization; Pharmacology; Proteins; Signal transduction; ANGPTLs; drug development; metabolism; oligomerization; integrin; inflammation
• ISSN: 0021-9541; 1097-4652
• DOI: 10.1002/jcp.30534

Angiopoietin‐like proteins (ANGPTLs), a family of eight secreted glycoproteins termed ANGTPL1‐8, are involved in angiogenesis, lipid metabolism, cancer progression, and inflammation. Their roles in regulating lipid metabolism have been intensively studied, as some ANGPTLs are promising pharmacological targets for hypertriglyceridemia and associated cardiovascular disease. Recently, the emerging roles of ANGPTLs in inflammation have attracted great attention. First, elevated levels of multiple circulating ANGPTLs in inflammatory diseases make them potential disease biomarkers. Second, multiple ANGPTLs regulate acute or chronic inflammation via various mechanisms, including triggering inflammatory signaling through their action as ligands for integrin or forming homo‐ /hetero‐oligomers to regulate signal transduction via extra‐ or intracellular mechanisms. As dysregulation of the inflammatory response is a critical trigger in many diseases, understanding the roles of ANGPTLs in inflammation will aid in drug/therapy development. Here, we summarize the roles, mechanisms, and potential therapeutic values for ANGPTLs in inflammation and inflammatory diseases. Angiopoietin‐like proteins (ANGPTLs) are promising pharmacological targets for hyperlipemia and atherosclerosis. Understanding the roles of ANGPTLs in inflammation will benefit their pharmacological research and related drug/therapy development. Here, we summarize the roles, mechanisms, and potential therapeutic values for ANGPTLs in inflammation and inflammatory diseases