Critical aspects of the physiological interactions between lead and magnesium

Despite technological progress, exposure to lead is an ongoing problem. There are many mechanisms governing the toxic effects of lead on the human body. One such mechanism involves the interaction of this xenobiotic with bivalent metal ions, including magnesium. Literature data suggest that the comp...

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Published inJournal of biochemical and molecular toxicology Vol. 36; no. 2; pp. e22964 - n/a
Main Authors Wyparło‐Wszelaki, Magdalena, Machoń‐Grecka, Anna, Wąsik, Marta, Dobrakowski, Michał
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.02.2022
Subjects
Binding sites
Gene expression
Gene Expression Regulation - drug effects
Human body
Humans
Immune response
lead
Lead - toxicity
Magnesium
Magnesium - metabolism
Metal ions
Oxidative stress
Oxidative Stress - drug effects
Toxicity
transcription factors
Xenobiotics - metabolism
Xenobiotics - toxicity
magnesium
immune response
transcription factors
lead
oxidative stress
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Summary:Despite technological progress, exposure to lead is an ongoing problem. There are many mechanisms governing the toxic effects of lead on the human body. One such mechanism involves the interaction of this xenobiotic with bivalent metal ions, including magnesium. Literature data suggest that the competition between these elements for binding sites at the molecular and cellular levels, as well as at the systemic level, may represent an important aspect of lead toxicity in the human body. This is especially clear in the context of oxidative stress, immune response, and gene expression modifications. This review aims to summarize current knowledge regarding these issues.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.22964