Anti‐EBV antibodies: Roles in diagnosis, pathogenesis, and antiviral therapy

Epstein‐Barr virus (EBV) infection is prevalent in global population and associated with multiple malignancies and autoimmune diseases. During the infection, EBV‐harbored or infected cell‐expressing antigen could elicit a variety of antibodies with significant role in viral host response and pathoge...

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Published inJournal of medical virology Vol. 95; no. 5; pp. e28793 - n/a
Main Authors Xie, Chu, Zhong, Lan‐Yi, Bu, Guo‐Long, Zhao, Ge‐Xin, Yuan, Bo‐Yu, Liu, Yuan‐Tao, Sun, Cong, Zeng, Mu‐Sheng
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.05.2023
Subjects
Antibodies
Antibodies, Viral
Antigens
Antiviral agents
Antiviral Agents - therapeutic use
Autoimmune diseases
Autoimmune Diseases - complications
Autoimmunity
Biomarkers
Diagnosis
Epstein-Barr virus
Epstein-Barr Virus Infections - complications
Epstein-Barr Virus Infections - diagnosis
Epstein-Barr Virus Infections - drug therapy
Epstein‐Barr virus (EBV)
Herpesvirus 4, Human
Humans
Malignancy
Multiple Sclerosis
multiple sclerosis (MS)
Pathogenesis
Pharmacology
prognosis
Virology
virus neutralization
multiple sclerosis (MS)
antibodies
virus neutralization
Epstein-Barr virus (EBV)
prognosis
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Summary:Epstein‐Barr virus (EBV) infection is prevalent in global population and associated with multiple malignancies and autoimmune diseases. During the infection, EBV‐harbored or infected cell‐expressing antigen could elicit a variety of antibodies with significant role in viral host response and pathogenesis. These antibodies have been extensively evaluated and found to be valuable in predicting disease diagnosis and prognosis, exploring disease mechanisms, and developing antiviral agents. In this review, we discuss the versatile roles of EBV antibodies as important biomarkers for EBV‐related diseases, potential driving factors of autoimmunity, and promising therapeutic agents for viral infection and pathogenesis.
Bibliography:Chu Xie, Lan‐Yi Zhong, and Guo‐Long Bu contributed equally to this study.
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ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.28793