Proinflammatory signaling functions of thrombin in cancer
Thrombin‐induced activation of protease‐activated receptors (PARs) represents a link between inflammation and cancer. Proinflammatory signaling functions of thrombin are associated with several inflammatory diseases including neurodegenerative, cardiovascular, and of special interest in this review...
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| Published in | Journal of cellular physiology Vol. 232; no. 9; pp. 2323 - 2329 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Wiley Subscription Services, Inc
01.09.2017
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| Abstract | Thrombin‐induced activation of protease‐activated receptors (PARs) represents a link between inflammation and cancer. Proinflammatory signaling functions of thrombin are associated with several inflammatory diseases including neurodegenerative, cardiovascular, and of special interest in this review cancer. Thrombin‐induced inflammatory responses up‐regulates expression of cytokines, adhesion molecules, angiogenic factors, and matrix‐degrading proteases that facilitate tumor cells proliferation, angiogenesis, invasion, and metastasis. This review summarizes the current knowledge about the mechanisms of thrombin‐mediated proinflammatory responses in cancer pathology for a better understanding and hence a better management of this disease.
Thrombin‐induced inflammatory responses up‐regulates expression of cytokines, adhesion molecules, angiogenic factors, and matrix‐degrading proteases that facilitate tumor cells proliferation, angiogenesis, invasion, and metastasis. This review summarizes the current knowledge about the mechanisms of thrombin‐mediated proinflammatory responses in cancer pathology for a better understanding and hence a better management of this disease. |
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| AbstractList | Thrombin‐induced activation of protease‐activated receptors (PARs) represents a link between inflammation and cancer. Proinflammatory signaling functions of thrombin are associated with several inflammatory diseases including neurodegenerative, cardiovascular, and of special interest in this review cancer. Thrombin‐induced inflammatory responses up‐regulates expression of cytokines, adhesion molecules, angiogenic factors, and matrix‐degrading proteases that facilitate tumor cells proliferation, angiogenesis, invasion, and metastasis. This review summarizes the current knowledge about the mechanisms of thrombin‐mediated proinflammatory responses in cancer pathology for a better understanding and hence a better management of this disease. Thrombin‐induced activation of protease‐activated receptors (PARs) represents a link between inflammation and cancer. Proinflammatory signaling functions of thrombin are associated with several inflammatory diseases including neurodegenerative, cardiovascular, and of special interest in this review cancer. Thrombin‐induced inflammatory responses up‐regulates expression of cytokines, adhesion molecules, angiogenic factors, and matrix‐degrading proteases that facilitate tumor cells proliferation, angiogenesis, invasion, and metastasis. This review summarizes the current knowledge about the mechanisms of thrombin‐mediated proinflammatory responses in cancer pathology for a better understanding and hence a better management of this disease. Thrombin‐induced inflammatory responses up‐regulates expression of cytokines, adhesion molecules, angiogenic factors, and matrix‐degrading proteases that facilitate tumor cells proliferation, angiogenesis, invasion, and metastasis. This review summarizes the current knowledge about the mechanisms of thrombin‐mediated proinflammatory responses in cancer pathology for a better understanding and hence a better management of this disease. |
| Author | Rahmani, Farzad Khazaie, Majid Keramati, Mohammad Reza Hoseinkhani, Fatemeh Avan, Amir Ebrahimi, Safieh Parizadeh, Mohammad Reza Behnam‐Rassouli, Reihane Hassanian, Seyed Mahdi |
| Author_xml | – sequence: 1 givenname: Safieh surname: Ebrahimi fullname: Ebrahimi, Safieh organization: Mashhad University of Medical Sciences – sequence: 2 givenname: Farzad surname: Rahmani fullname: Rahmani, Farzad organization: Mashhad University of Medical Sciences – sequence: 3 givenname: Reihane surname: Behnam‐Rassouli fullname: Behnam‐Rassouli, Reihane organization: Islamic Azad University – sequence: 4 givenname: Fatemeh surname: Hoseinkhani fullname: Hoseinkhani, Fatemeh organization: Iran University of Medical Sciences – sequence: 5 givenname: Mohammad Reza surname: Parizadeh fullname: Parizadeh, Mohammad Reza organization: Mashhad University of Medical Sciences – sequence: 6 givenname: Mohammad Reza surname: Keramati fullname: Keramati, Mohammad Reza organization: Mashhad University of Medical Sciences – sequence: 7 givenname: Majid surname: Khazaie fullname: Khazaie, Majid organization: Mashhad University of Medical Sciences – sequence: 8 givenname: Amir surname: Avan fullname: Avan, Amir email: avana@mums.ac.ir organization: Mashhad University of Medical Sciences – sequence: 9 givenname: Seyed Mahdi orcidid: 0000-0002-5247-4043 surname: Hassanian fullname: Hassanian, Seyed Mahdi email: hasanianmehrm@mums.ac.ir organization: Mashhad University of Medical Sciences |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28004386$$D View this record in MEDLINE/PubMed |
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| Snippet | Thrombin‐induced activation of protease‐activated receptors (PARs) represents a link between inflammation and cancer. Proinflammatory signaling functions of... Thrombin-induced activation of protease-activated receptors (PARs) represents a link between inflammation and cancer. Proinflammatory signaling functions of... |
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| SubjectTerms | Angiogenesis Angiogenic Proteins - metabolism Animals Cancer Cell Adhesion Molecules Cell Movement Cell Proliferation Cytokines Cytokines - metabolism Disease control Humans inflammation Inflammation - metabolism Inflammation - pathology Inflammation Mediators - metabolism Inflammatory diseases Metastases Neoplasm Metastasis Neoplasms - metabolism Neoplasms - pathology Neovascularization, Pathologic Peptide Hydrolases protease‐activated receptors (PARs) Receptors Receptors, Proteinase-Activated - metabolism Signal Transduction Thrombin Thrombin - metabolism Tumor cells |
| Title | Proinflammatory signaling functions of thrombin in cancer |
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