Proinflammatory signaling functions of thrombin in cancer

• Published in: Journal of cellular physiology Vol. 232; no. 9; pp. 2323 - 2329
• Main Authors: Ebrahimi, Safieh, Rahmani, Farzad, Behnam‐Rassouli, Reihane, Hoseinkhani, Fatemeh, Parizadeh, Mohammad Reza, Keramati, Mohammad Reza, Khazaie, Majid, Avan, Amir, Hassanian, Seyed Mahdi
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.09.2017
• Subjects: Angiogenesis; Angiogenic Proteins - metabolism; Animals; Cancer; Cell Adhesion Molecules; Cell Movement; Cell Proliferation; Cytokines; Cytokines - metabolism; Disease control; Humans; inflammation; Inflammation - metabolism; Inflammation - pathology; Inflammation Mediators - metabolism; Inflammatory diseases; Metastases; Neoplasm Metastasis; Neoplasms - metabolism; Neoplasms - pathology; Neovascularization, Pathologic; Peptide Hydrolases; protease‐activated receptors (PARs); Receptors; Receptors, Proteinase-Activated - metabolism; Signal Transduction; Thrombin; Thrombin - metabolism; Tumor cells; protease-activated receptors (PARs); cancer; thrombin; inflammation
• ISSN: 0021-9541; 1097-4652
• DOI: 10.1002/jcp.25753

Thrombin‐induced activation of protease‐activated receptors (PARs) represents a link between inflammation and cancer. Proinflammatory signaling functions of thrombin are associated with several inflammatory diseases including neurodegenerative, cardiovascular, and of special interest in this review cancer. Thrombin‐induced inflammatory responses up‐regulates expression of cytokines, adhesion molecules, angiogenic factors, and matrix‐degrading proteases that facilitate tumor cells proliferation, angiogenesis, invasion, and metastasis. This review summarizes the current knowledge about the mechanisms of thrombin‐mediated proinflammatory responses in cancer pathology for a better understanding and hence a better management of this disease. Thrombin‐induced inflammatory responses up‐regulates expression of cytokines, adhesion molecules, angiogenic factors, and matrix‐degrading proteases that facilitate tumor cells proliferation, angiogenesis, invasion, and metastasis. This review summarizes the current knowledge about the mechanisms of thrombin‐mediated proinflammatory responses in cancer pathology for a better understanding and hence a better management of this disease.