Association between the zinc finger protein 804A (ZNF804A) gene and the risk of schizophrenia and bipolar I disorder across diagnostic boundaries

• Published in: Bipolar disorders Vol. 19; no. 4; pp. 305 - 313
• Main Authors: Baek, Ji Hyun, Ha, Kyooseob, Kim, Yongkang, Yang, So Yung, Cho, Eun‐Young, Choi, Yujin, Ryu, Seunghyong, Lee, Yu‐Sang, Park, Taesung, Hong, Kyung Sue
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.06.2017
• Subjects: Adult; Bipolar disorder; Bipolar Disorder - diagnosis; Bipolar Disorder - genetics; Diagnostic and Statistical Manual of Mental Disorders; Female; genetic association; Genetic diversity; Genetic Predisposition to Disease; Humans; Kruppel-Like Transcription Factors - genetics; Male; Mental disorders; Middle Aged; Polymorphism; Polymorphism, Single Nucleotide; Psychosis; Psychotic Disorders - diagnosis; Psychotic Disorders - genetics; Regression analysis; Republic of Korea; Schizophrenia; Schizophrenia - diagnosis; Schizophrenia - genetics; Single-nucleotide polymorphism; zinc finger protein 804A (ZNF804A); Zinc finger proteins; Zinc Fingers - genetics; genetic association; zinc finger protein 804A (ZNF804A); bipolar disorder; schizophrenia; psychosis
• ISSN: 1398-5647; 1399-5618
• DOI: 10.1111/bdi.12493

Objectives In this study, we aimed to determine the role of genetic variations within the zinc finger protein 804A (ZNF804A) gene, a candidate for a psychosis risk‐conferring gene, in the development of schizophrenia (SZ) and bipolar disorder (BP) in the Korean population. Methods A total of 921 patients with SZ, bipolar I (BP‐I) and II (BP‐II) disorder, and 502 control subjects participated in the study. Twenty‐one tag single nucleotide polymorphisms (SNPs) across the genomic region of ZNF804A and seven reference SNPs based on previous reports were genotyped. We applied logistic regression analyses under additive, dominant and recessive models. Results Fifteen of the 28 SNPs showed a nominally significant association with at least one diagnostic group. However, none of these associations remained significant after false discovery rate (FDR) correction. As the trend of association was observed mostly in SZ and BP‐I with similar patterns, we performed a post hoc analysis for the combined SZ and BP‐I group. Five SNPs (rs2369595, rs6755404, rs10931156, rs12476147 and rs1366842) showed a significant association with an FDR‐corrected P of <.05. Conclusions This study supports a possible role of ZNF804A in the common susceptibility of major psychoses, and identified additional candidate variants of the gene in the Korean population.