The interaction between obesity and visceral hypersensitivity

• Published in: Journal of gastroenterology and hepatology Vol. 38; no. 3; pp. 370 - 377
• Main Authors: Yanping, Wu, Gao, Xuefen, Cheng, Yizun, Liu, Mi, Liao, Siyu, Zhou, Jing, Hao, Jiaming, Jiang, Gemeng, Lu, Yixuan, Qu, Tianyao, Qin, Bin, Cheng, Yan
• Format: Journal Article
• Language: English
• Published: Australia Wiley Subscription Services, Inc 01.03.2023
• Subjects: Adipose tissue; Cardiovascular diseases; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - metabolism; Humans; Hypersensitivity; Inflammation; Intestinal Mucosa - metabolism; Intestine; Intestines; Irritable bowel syndrome; Irritable Bowel Syndrome - metabolism; Metabolic disorders; Microbiota; Nerve endings; Obesity; Vitamin D; Vitamin deficiency; microbiota; inflammation; irritable bowel syndrome; vitamin D; obesity
• ISSN: 0815-9319; 1440-1746
• DOI: 10.1111/jgh.16083

Obesity has been a worldwide problem associated with numerous chronic diseases such as cardiovascular disease, type 2 diabetes, and metabolic disorders. It may also play a role in visceral hypersensitivity, contributing to irritable bowel syndrome. (i) Adipose tissue secretes various inflammatory mediators, causing intestinal hyperpermeability and nerve endings activation. (ii) Obesity and gastrointestinal microbiota could affect each other, and microbial metabolites can increase sensitivity of the colon. (iii) Vitamin D deficiency contributes to both fat accumulation and disruption of the intestinal mucosal barrier. (iv) Brain‐gut axis may be another bridge from obesity to visceral hypersensitivity.