Hepatotoxic effects elicited by n-hexane or n-heptane

Hepatotoxic effects of n-hexane and n-heptane administered i.p. (1 ml/kg body wt) were studied in albino rats after 1, 2, 7 and 45 days of treatment. Hepatic protein content decreased with n-heptane and total sulphydryl content showed a significant decrease in the rats exposed to either solvent. A s...

Full description

Saved in:
Bibliographic Details
Published inJournal of applied toxicology Vol. 8; no. 2; p. 81
Main Authors Goel, S K, Rao, G S, Pandya, K P
Format Journal Article
LanguageEnglish
Published England 01.04.1988
Subjects
Animals
Chemical and Drug Induced Liver Injury - enzymology
Chemical and Drug Induced Liver Injury - etiology
Female
Glucose-6-Phosphatase - metabolism
Heptanes - poisoning
Hexanes - poisoning
Lipid Peroxides - metabolism
Liver - drug effects
Liver - enzymology
Liver - metabolism
Mixed Function Oxygenases - metabolism
Pentobarbital - pharmacology
Proteins - metabolism
Rats
Sleep - drug effects
Subcellular Fractions - metabolism
Sulfhydryl Compounds - metabolism
Online AccessGet more information

Cover

More Information
Summary:Hepatotoxic effects of n-hexane and n-heptane administered i.p. (1 ml/kg body wt) were studied in albino rats after 1, 2, 7 and 45 days of treatment. Hepatic protein content decreased with n-heptane and total sulphydryl content showed a significant decrease in the rats exposed to either solvent. A significant increase in lipid peroxidation was observed after 24 h and 48 h exposure to n-hexane or n-heptane. A marked decrease in drug metabolizing activity and an increase in pentabarbitone sleeping time was also observed. Hepatic glucose-6-phosphatase, a microsomal marker enzyme, showed a significant decrease.
ISSN:0260-437X
DOI:10.1002/jat.2550080203