Non‐celiac gluten or wheat sensitivity: It's complicated

• Published in: Neurogastroenterology and motility Vol. 30; no. 8; pp. e13392 - n/a
• Main Authors: Pinto‐Sanchez, Maria I., Verdu, Elena F.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.08.2018
• Subjects: Allergies; Celiac disease; Clinical trials; Diagnosis; Food allergies; Gastroenterology; Gluten; gluten sensitivity; gluten‐sensitive IBS; non‐celiac gluten sensitivity; non‐celiac wheat sensitivity; Remission; non-celiac wheat sensitivity; gluten-sensitive IBS; gluten sensitivity; non-celiac gluten sensitivity
• ISSN: 1350-1925; 1365-2982
• DOI: 10.1111/nmo.13392

In the last 30 years, non‐celiac gluten sensitivity (NCGS) has emerged as an intriguing and controversial topic in gastroenterology. The diagnosis of NCGS/NCWS requires a symptomatic reaction to gluten, or wheat‐containing food, and remission of symptoms with gluten or wheat challenge, in patients in whom celiac disease and wheat allergy have been excluded. There have been several randomized clinical trials (RCT) addressing this issue which have produced controversial results. In this issue of Neurogastroenterology and Motility, a double‐blind placebo‐controlled randomized trial in patients with suspected NCGS on GFD, did not reproduce symptoms after gluten intake compared to placebo. This mini‐review addresses outstanding issues related to the diagnosis of NCGS/NCWS as well as areas of interest for future studies that could explain, in part, the controversy in this area.