Could circRNA be a new biomarker for pre‐eclampsia?

• Published in: Molecular reproduction and development Vol. 86; no. 12; pp. 1773 - 1780
• Main Authors: Shafabakhsh, Rana, Mirhosseini, Naghmeh, Chaichian, Shala, Moazzami, Bahram, Mahdizadeh, Zahra, Asemi, Zatollah
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2019
• Subjects: Biomarkers; circRNA; diagnosis; Eclampsia; Fetuses; prediction; Preeclampsia; pregnancy; Pregnancy complications; pre‐eclampsia; Proteinuria; Quality of life; Ribonucleic acid; Risk factors; RNA; Womens health; prediction; diagnosis; pre-eclampsia; circRNA; pregnancy
• ISSN: 1040-452X; 1098-2795; 1098-2795
• DOI: 10.1002/mrd.23262

Pre‐eclampsia is a devastating complication of pregnancy which is characterized by hypertension and proteinuria in pregnant women. Pre‐eclampsia is important as it is the leading cause of death. Moreover, untreated pre‐eclampsia might lead to other lethal complications, for both fetus and mother. Pre‐eclampsia can also affect the quality of life in affected women. Despite a large number of risk factors for pre‐eclampsia, these risk factors are able to detect just 30% of women who are susceptible to pre‐eclampsia. Heterogeneous manifestations of pre‐eclampsia necessitate the discovery of potential biomarkers required for its early detection. Circular RNAs (circRNAs) are a type of RNA which are more abundant, specific, and highly organized compared with other types of RNA. Accordingly, circRNAs have been suggested as one of the potential biomarkers for different diseases. Recently, researchers have shown interest in the effects of circRNAs in pre‐eclampsia, although the current evidence is limited. The majority of obstetricians are probably not aware of circRNAs as a useful biomarker. Here, we aimed to summarize recent supporting evidence and assess the mechanisms by which circRNAs are involved in pre‐eclampsia. Pre‐eclampsia can also affect the quality of life in affected women. However, researchers have determined a large number of risk factors for pre‐eclampsia, these risk factors are able to detect just 30% of women who are prone to affect by pre‐eclampsia. Thus, due to its heterogeneous manifestations, potential biomarkers are required for its early detection. Circular RNAs (circRNAs) are a type of RNAs which are more abundant, more specific, and higher organized in compared with other RNAs. Accordingly, it has been suggested that circRNAs may be potential biomarkers for various diseases. In recent years, the effects of circRNAs in pre‐eclampsia have become interesting for researchers and various studies have been conducted herein.