The impact of pediatric hematopoietic stem cell transplant timing and psychosocial factors on family and caregiver adjustment

• Published in: Pediatric blood & cancer Vol. 67; no. 11; pp. e28552 - n/a
• Main Authors: Chardon, Marie L., Canter, Kimberly S., Pai, Ahna L.H., Peugh, James L., Madan‐Swain, Avi, Vega, Gabriela, Joffe, Naomi E., Kazak, Anne E.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.11.2020
• Subjects: Adaptation, Psychological; Adolescent; Adult; Age; Caregivers; Caregivers - psychology; Child; Child, Preschool; Children; Children & youth; Delivery of Health Care - standards; Diagnosis; Electronic medical records; Family - psychology; family adjustment; Female; Follow-Up Studies; Hematologic Neoplasms - psychology; Hematologic Neoplasms - therapy; Hematology; hematology/oncology; Hematopoietic Stem Cell Transplantation - psychology; Hematopoietic stem cells; Humans; Infant; Male; Oncology; pediatric; Pediatrics; Prognosis; Psychological assessment; Psychosocial Support Systems; Quality of Life; Social interactions; Socioeconomic Factors; Stem cell transplantation; Stem cells; Stress, Psychological - psychology; Surveys and Questionnaires; Young Adult; family adjustment; hematology/oncology; stem cell transplantation; pediatric
• ISSN: 1545-5009; 1545-5017
• DOI: 10.1002/pbc.28552

Background The impact of pediatric hematopoietic stem cell transplant (HCT) on family functioning varies, but little is known about how the timing of HCT in children's treatment course contributes to this variability. This study examines how preexisting child, sibling, and family problems, the length of time between diagnosis to HCT, and children's age at HCT are associated with family and caregiver functioning. Procedure Caregivers (n = 140) of children (≤18 years old) scheduled to undergo their first HCT completed the Psychological Assessment Tool‐HCT and the Impact on Family Scale. Treatment information was extracted from electronic medical records. A bootstrapped multivariate path analysis was used to test the hypotheses. Results More preexisting family problems related to greater caregiver perceived negative impact of their child's HCT across family and caregiver functioning domains. Less time between diagnosis and HCT was associated with greater caregiver personal strain, particularly for those with younger children undergoing HCT. Younger child age at HCT was also associated with a larger negative impact on family social functioning. Conclusions Families with preexisting problems are the most at‐risk for experiencing negative impacts related to their child's HCT. The timing of a child's HCT within their treatment course and the child's age during HCT may impact families’ social functioning and caregiver adjustment. Screening families for preexisting family problems, particularly for families with young children or who are abruptly learning of their child's need for an HCT, may assist providers in identifying families who would benefit from earlier or more intensive psychosocial support.