Extra‐acral cutaneous sclerosing perineurioma with CD34 fingerprint pattern

• Published in: Journal of cutaneous pathology Vol. 44; no. 4; pp. 388 - 392
• Main Authors: Macarenco, Ricardo S., Cury‐Martins, Jade
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.04.2017; Wiley Subscription Services, Inc
• Subjects: Actin; Antigens, CD34 - metabolism; Case reports; CD34 antigen; CD34 fingerprint; cutaneous perineurioma; dermoscopy; Desmin; fibroblast; Glucose transporter; Head and Neck Neoplasms - metabolism; Head and Neck Neoplasms - pathology; Humans; Male; Middle Aged; Neck; Neoplasm Proteins - metabolism; Nerve Sheath Neoplasms - metabolism; Nerve Sheath Neoplasms - pathology; Protein transport; sclerosing perineurioma; Skin; Skin Neoplasms - metabolism; Skin Neoplasms - pathology; Smooth muscle; fibroblast; sclerosing perineurioma; CD34 fingerprint; cutaneous perineurioma; dermoscopy
• ISSN: 0303-6987; 1600-0560
• DOI: 10.1111/cup.12882

Sclerosing perineuroma is a variant of extraneural perineurioma that, as a rule, occurs in acral sites. However, it has also been occasionally reported in non‐acral regions. Recently, CD34 expression in a pattern reminiscent of the human fingerprint has been observed in a subset of perineuriomas, but this immunohistochemical finding has not been documented in non‐acral sclerosing perineuriomas. We report a case of sclerosing perineurioma presenting CD34 expression in a fingerprint‐like pattern on the skin of the neck (a previously unreported site for this neoplasm) of a 56‐year‐old man. In addition, alpha smooth‐muscle actin showed a similar pattern of expression, suggesting that the cell population implicated in the remarkable immunolabeling is most probably fibroblastic/myofibroblastic. Other immunohistochemical findings included epithelial membrane antigen and claudin1—positive lesional cells, and the absence of S100, glucose transporter protein 1, MUC4 and desmin.