Microvasculature dropout detected by the optical coherence tomography angiography in nonarteritic anterior ischemic optic neuropathy

• Published in: Lasers in surgery and medicine Vol. 50; no. 3; pp. 194 - 201
• Main Authors: Song, Yi, Min, Jing‐yu, Mao, Lei, Gong, Yuan‐yuan
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2018
• Subjects: Angiography; Density; Eye; Eye (anatomy); Ischemia; Lasers; Medical imaging; Microvasculature; nonarteritic anterior ischemic optic neuropathy; OCT angiography; Optic neuropathy; Optical Coherence Tomography; Optics; Patients; Retina; split‐spectrum amplitude‐decorrelation angiography; Tomography; vascular density; OCT angiography; vascular density; nonarteritic anterior ischemic optic neuropathy; split-spectrum amplitude-decorrelation angiography
• ISSN: 0196-8092; 1096-9101
• DOI: 10.1002/lsm.22712

Objective To investigate microcirculation characteristics of peripapillary superficial retina and optic disc in eyes with nonarteritic anterior ischemic optic neuropathy (NAION) using optical coherence tomography angiography (OCTA). Methods Forty‐one eyes of 30 NAION patients and 30 eyes of 30 normal subjects were evaluated with OCTA (AngioVue, Optovue). The whole vessel density, inside disc vessel density, peripapillary vessel density, and vessel densities based on the sectorial division in the nerve head mode peripapillary superficial retina and RPC mode optic disc were measured respectively. Results In the NAION group, vessel densities in both the peripapillary superficial retina and optic disc were significant reduced (P < 0.01), as compared with the control group. The whole vessel density of the optic disc in chronic NAION group were significantly lower than that in acute NAION group (P < 0.01). The whole and temporal vessel density of the peripapillary superficial retina was significantly correlated with log MAR VA (r = −0.381 and r = −0.337, both P < 0.05). Vessel densities in both the peripapillary superficial retina and optic disc were reduced (P < 0.05) in unilateral involved eyes, as compared to the unaffected fellow eyes, except for the inside disc (P = 0.270) and SN (P = 0.054) vessel density in the optic disc, while there was no difference in the fellow eyes compared to the normal eyes. Conclusion In NAION patients, a dropout of microvasculature in peripapillary superficial retina and optic disc could be detected by OCTA directly. OCTA might become a useful tool for detection and monitoring of NAION. Lasers Surg. Med. 50:194–201, 2018. © 2017 Wiley Periodicals, Inc.