Investigation of a new horizon antifungal activity with enhancing the antimicrobial efficacy of ciprofloxacin and its binary mixture via their encapsulation in nanoassemblies: in vitro and in vivo evaluation

The main goal of this study was to prepare and evaluate nanosponges containing ciprofloxacin (CIP) or its binary mixture with N‐acetyl carnosine (NAC). Nanosponges were prepared by ultrasound‐assisted synthesis technique using hydroxypropyl βeta‐cyclodextrin (HPβ‐CD), as the polymer and diphenyl car...

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Bibliographic Details
Published inDrug development research Vol. 81; no. 3; pp. 374 - 388
Main Authors Abou Taleb, Sally, Darwish, Asmaa Badawy, Abood, Amira, Mohamed, Amany M.
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.05.2020
Wiley Subscription Services, Inc
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Summary:The main goal of this study was to prepare and evaluate nanosponges containing ciprofloxacin (CIP) or its binary mixture with N‐acetyl carnosine (NAC). Nanosponges were prepared by ultrasound‐assisted synthesis technique using hydroxypropyl βeta‐cyclodextrin (HPβ‐CD), as the polymer and diphenyl carbonate (DPC) as the crosslinker. Entrapment efficiency (EE%) of CIP or its binary mixture with NAC in nanosponges was deduced spectrophotometrically. Nanosponges were characterized using several methods. EE% of CIP or its binary mixture with NAC inside nanosponges ranged from 98.63 ± 3.1 to 100 ± 0.07%. Particle size of nanosponges ranged from 66.7 to 90.1 nm. Release of drugs from nanosponges was biphasic and the release pattern followed Korsmeyer–Peppas model. Ex vivo and in vivo studies results showed that the antibacterial effect was enhanced with encapsulation of drugs in the nanosponge system. Furthermore, a potent antifungal activity was obtained from all examined formulae against Candida albicans (10231). The study revealed that successful encapsulation of CIP or its binary mixture with NAC in nanosponge formulations has innovated a new promising therapeutic activity for both drugs.
Bibliography:Funding information
National Research Centre; National Research Centre, Egypt
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0272-4391
1098-2299
DOI:10.1002/ddr.21632