IL17RB expression is associated with malignant cancer behaviors and poor prognosis in oral cancer

• Published in: Oral diseases Vol. 30; no. 4; pp. 2027 - 2038
• Main Authors: Yuan, Shyng‐Shiou F., Su, Chang‐Wei, Chan, Leong‐Perng, Nguyen, Hieu D. H., Chen, Yuk‐Kwan, Du, Je‐Kang, Cheng, Kuang‐Hung, Wang, Yen‐Yun
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.05.2024
• Subjects: Adult; Aged; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - pathology; Cell adhesion & migration; Cell Line, Tumor; Cell migration; Cell Movement; Chemotherapy; Female; Gene expression; Humans; IL17RB; Immunohistochemistry; Lung cancer; Lymph nodes; Lymphatic Metastasis; Male; Medical prognosis; Metastases; Middle Aged; Mouth Neoplasms - genetics; Mouth Neoplasms - metabolism; Mouth Neoplasms - pathology; Neoplasm Staging; Oral cancer; Oral carcinoma; Oral squamous cell carcinoma; patient survival; Prognosis; Radiation therapy; Receptors, Interleukin-17 - genetics; Receptors, Interleukin-17 - metabolism; Risk factors; Targeted cancer therapy; therapeutic target; Therapeutic targets; Western blotting; therapeutic target; patient survival; IL17RB; oral cancer
• ISSN: 1354-523X; 1601-0825; 1601-0825
• DOI: 10.1111/odi.14672

Objectives Previously, we demonstrated that IL17RB plays an essential role in lung cancer progression. This study aimed to determine whether IL17RB correlates with oral cancer and promotes oral cancer progression. Subjects and Methods IL17RB expression in oral cancer tissues and normal tissues was determined by immunohistochemistry staining, while the association of IL17RB expression with the clinicopathological characteristics of oral squamous cell carcinoma (OSCC) patients was analyzed and its correlation with progression‐free survival and response to radiotherapy and chemotherapy in OSCC patients was also explored. Western blotting was performed to investigate the expression of IL17RB in various OSCC cell lines; moreover, transwell assay was performed to evaluate the effect of IL17RB expression on cell migration ability. Results In this study, we found that IL17RB was expressed higher in OSCC tissues compared to normal oral mucosa tissues and its expression was positively correlated with tumor size, lymph node metastasis, advanced cancer stage, and poor prognosis. In vitro study showed that IL17RB expression in OSCC cell lines as determined by Western blotting, was positively correlated with their migration ability. Conclusion Clinical and in vitro studies suggest that IL17RB might serve as an independent risk factor and a therapeutic target for oral cancer.