Sarcopenia and survival in colorectal cancer without distant metastasis: a systematic review and meta‐analysis

Background and Aim Despite prior attempts to evaluate the effects of sarcopenia on survival among patients with colorectal cancer (CRC), the results of these studies have not been consistent. The present study aimed to evaluate the association between sarcopenia and survival among patients having CR...

Full description

Saved in:
Bibliographic Details
Published inJournal of gastroenterology and hepatology Vol. 39; no. 11; pp. 2250 - 2259
Main Authors Lin, Wen‐Li, Nguyen, Thi‐Hoang‐Yen, Huang, Wen‐Tsung, Guo, How‐Ran, Wu, Li‐Min
Format Journal Article
LanguageEnglish
Published Australia Wiley Subscription Services, Inc 01.11.2024
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Disease-Free Survival
Female
Humans
Male
Meta-analysis
Metastases
Metastasis
Middle Aged
mortality
Sarcopenia
Sarcopenia - etiology
Sarcopenia - mortality
Survival
Survival Rate
systematic review
Tumors
Young Adult
mortality
colorectal cancer
meta‐analysis
systematic review
survival
sarcopenia
Online AccessGet full text

Cover

More Information
Summary:Background and Aim Despite prior attempts to evaluate the effects of sarcopenia on survival among patients with colorectal cancer (CRC), the results of these studies have not been consistent. The present study aimed to evaluate the association between sarcopenia and survival among patients having CRC without distant metastasis by aggregating multiple studies. Methods We performed a literature search using computerized databases and identified additional studies from among the bibliographies of retrieved articles. The quality of each study was evaluated using the Newcastle–Ottawa Scale, and meta‐analyses were performed to evaluate overall survival (OS) and disease‐free survival (DFS). Results Thirteen studies with up to 6600 participants were included in the meta‐analyses, with a mean age of 63.6 years (range: 18–93 years). We found that preoperative sarcopenia was associated with worse OS (hazard ratio [HR]: 1.61; 95% confidence interval [CI]: 1.38–1.88) and worse DFS (HR: 1.57; 95% CI: 1.10–2.24). Compared with patients without sarcopenia after tumor resection, those with postoperative sarcopenia had worse OS (HR: 1.76; 95% CI: 1.47–2.10) and DFS (HR: 1.79; 95% CI: 1.46–2.20). Conclusion These meta‐analyses suggest that sarcopenia, no matter observed before or after tumor resection, is associated with worse OS and DFS in patients with CRC who have no distant metastasis. ▪
Bibliography:Wen‐Tsung Huang, How‐Ran Guo, and Li‐Min Wu contributed equally to this work.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-4
content type line 23
ObjectType-Undefined-3
ISSN:0815-9319
1440-1746
1440-1746
DOI:10.1111/jgh.16681