Exploring the causal inference of migraine on stroke: A Mendelian randomization study
Background and purpose Previous observational studies have reported that patients with migraine have an increased risk of stroke. We explored whether migraine has a causal effect on stroke using a two‐sample Mendelian randomization approach. Methods Genetic instruments were selected from large genom...
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Published in | European journal of neurology Vol. 29; no. 1; pp. 335 - 338 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
John Wiley & Sons, Inc
01.01.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Background and purpose
Previous observational studies have reported that patients with migraine have an increased risk of stroke. We explored whether migraine has a causal effect on stroke using a two‐sample Mendelian randomization approach.
Methods
Genetic instruments were selected from large genome‐wide association studies of migraine and stroke. A two‐sample Mendelian randomization analysis was performed, along with sensitivity analysis. We used migraine subtypes (any migraine, migraine with aura, migraine without aura) as risk factors and stroke, ischemic stroke, and hemorrhagic stroke as outcomes for this analysis. Ischemic stroke subtypes were also included to explore the underlying pathogenesis linking migraine to stroke.
Results
Migraine did not show any association with stroke (odds ratio [OR], 0.95; 95% confidence interval [CI], 0.87–1.03), ischemic stroke (OR, 0.93; 95% CI, 0.85–1.02), or hemorrhagic stroke (OR, 1.26; 95% CI, 0.84–1.91), suggesting that the observed association may not be causal. Neither migraine with aura nor without aura showed causal relationship with outcomes. The sensitivity analysis supported the results of the primary analysis. Regarding ischemic stroke subtypes, migraine seemed to have a negative association with large‐artery atherosclerosis (OR, 0.81; 95% CI, 0.68–0.95), whereas associations with small‐vessel occlusion or cardioembolism were not evident.
Conclusions
Contrary to previous observational studies, we were unable to find any causal relationship between migraine and stroke. However, the suggested negative association of migraine in large‐artery atherosclerosis warrants further research.
Using a two‐sample Mendelian randomization approach, there was no causal relationship between migraine and stroke. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1351-5101 1468-1331 |
DOI: | 10.1111/ene.15101 |