A case of hyperprolactinemia and delusion of pregnancy during clozapine treatment

Clozapine (Clozaril, Novartis) is classified as a prolactin-sparing antipsychotic, so clozapine-induced hyperprolactinemia is rare. Herein, however, we present a case of severe hyperprolactinemia with delusion of pregnancy during the use of clozapine. We discuss various factors involved in the backg...

Full description

Saved in:
Bibliographic Details
Published inClinical Neuropsychopharmacology and Therapeutics Vol. 12; pp. 1 - 4
Main Authors Onda, Keigo, Yukawa, Takayuki, Inoue, Emiko, Tsuboya, Ryusuke, Sakaue, Masashi, Someya, Toshiyuki
Format Journal Article
LanguageEnglish
Published The Japanese Society of Clinical Neuropsychopharmacology 14.01.2021
Subjects
Clozapine
CPMS
delusion of pregnancy
hyperprolactinemia
prolactin-sparing antipsychotic
psychopharmacology
Online AccessGet full text

Cover

More Information
Summary:Clozapine (Clozaril, Novartis) is classified as a prolactin-sparing antipsychotic, so clozapine-induced hyperprolactinemia is rare. Herein, however, we present a case of severe hyperprolactinemia with delusion of pregnancy during the use of clozapine. We discuss various factors involved in the background of hyperprolactinemia and delusion of pregnancy. While clozapine-induced hyperprolactinemia is rare, the adverse events of this condition can be clinically important in the short- and long-term. In Japan, the measurement of prolactin levels is not a required item in the Clozaril Patient Monitoring Service (CPMS, Novartis), so the risk of hyperprolactinemia tends to be easily overlooked. We hope this case report will help to alert colleagues to the risk of hyperprolactinemia during clozapine use.
ISSN:1884-8826
1884-8826
DOI:10.5234/cnpt.12.1