Type VI secretion system effector proteins: Effective weapons for bacterial competitiveness

The Type VI secretion system (T6SS) is a protein translocation nanomachine widespread among Gram‐negative bacteria and used as a means to deliver effectors directly into target bacterial or eukaryotic cells. These effectors have a wide variety of functions within target cells that ultimately help th...

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Bibliographic Details
Published inCellular microbiology Vol. 22; no. 9; pp. e13241 - n/a
Main Authors Hernandez, Ruth E., Gallegos‐Monterrosa, Ramses, Coulthurst, Sarah J.
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Inc 01.09.2020
Subjects
Bacteria
bacterial competition
Competitiveness
Effectors
Gram-negative bacteria
protein secretion
Protein transport
Proteins
Secretion
Translocation
Type VI secretion system
effectors
bacterial competition
protein secretion
Type VI secretion system
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Summary:The Type VI secretion system (T6SS) is a protein translocation nanomachine widespread among Gram‐negative bacteria and used as a means to deliver effectors directly into target bacterial or eukaryotic cells. These effectors have a wide variety of functions within target cells that ultimately help the secreting cell gain a competitive fitness advantage. Here, we discuss the different ways in which these effectors can be delivered by the T6SS and the diverse mechanisms by which they exert their noxious action upon recipient cells. We also highlight the existence of roles for T6SS effectors beyond simply the killing of neighbouring cells.
Bibliography:Funding information
Wellcome Trust, Grant/Award Number: 104556/Z/14/Z
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ISSN:1462-5814
1462-5822
1462-5822
DOI:10.1111/cmi.13241