MYC and NOTCH1‐positive postradiation cutaneous angiosarcoma of the breast

Postradiation cutaneous angiosarcoma of the breast is a rare, delayed complication of adjuvant radiation treatment for breast carcinoma and is associated with a worse prognosis than the original primary cancer. Recent studies have characterized the diagnostic utility of MYC and NOTCH1 receptor expre...

Full description

Saved in:
Bibliographic Details
Published inThe breast journal Vol. 27; no. 3; pp. 264 - 267
Main Authors Sheu, Tiffany G., Hunt, Kelly K., Middleton, Lavinia P.
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.03.2021
Subjects
angiosarcoma
Breast
Breast carcinoma
Breast Neoplasms - radiotherapy
Cancer
Female
Hemangiosarcoma - etiology
Humans
Immunoreactivity
Markers
MYC
Myc protein
Neoplasms, Radiation-Induced - diagnosis
Neoplasms, Radiation-Induced - etiology
NOTCH1
Notch1 protein
Proto-Oncogene Proteins c-myc
Radiation
Receptor, Notch1 - genetics
angiosarcoma
NOTCH1
breast carcinoma
MYC
Online AccessGet full text

Cover

More Information
Summary:Postradiation cutaneous angiosarcoma of the breast is a rare, delayed complication of adjuvant radiation treatment for breast carcinoma and is associated with a worse prognosis than the original primary cancer. Recent studies have characterized the diagnostic utility of MYC and NOTCH1 receptor expression as markers for secondary radiation‐associated angiosarcomas. Herein, we report an exophytic secondary breast angiosarcoma with MYC and NOTCH1 immunoreactivity. This case illustrates the utility of these markers for the identification of radiation‐associated angiosarcoma with MYC and NOTCH1 expression, potential for targeted therapy and need to identify patients for further studies of the clinicopathologic and prognostic significance.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1075-122X
1524-4741
DOI:10.1111/tbj.14171