Fine specificity of the humoral immune response to HIV-1 GP160 in HIV-1 infected individuals from Tanzania

A total of 160 sera from HIV-1 infected individuals from Tanzania were examined for their fine specificity characteristics relative to 9 synthetic peptides that define HIV-1 gp160 epitopes. Immunorecessive and immunodominant epitopes were identified in both gp120 and gp41 based on serologic reactivi...

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Bibliographic Details
Published inJournal of medical virology Vol. 37; no. 1; p. 61
Main Authors Nkya, W M, Warren, R Q, Wolf, H, Hendrix, C W, Tesha, J, Redfield, R R, Melcher, G P, Burke, D S, Kanda, P, Kennedy, R C
Format Journal Article
LanguageEnglish
Published United States 01.05.1992
Subjects
Amino Acid Sequence
Antibody Specificity
Gene Products, env - immunology
HIV Antibodies - blood
HIV Antibodies - immunology
HIV Antigens - immunology
HIV Envelope Protein gp160
HIV Infections - immunology
HIV-1 - immunology
Humans
Molecular Sequence Data
Protein Precursors - immunology
Sensitivity and Specificity
Tanzania
United States
United States
Tanzania
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Summary:A total of 160 sera from HIV-1 infected individuals from Tanzania were examined for their fine specificity characteristics relative to 9 synthetic peptides that define HIV-1 gp160 epitopes. Immunorecessive and immunodominant epitopes were identified in both gp120 and gp41 based on serologic reactivity of these HIV-1 infected sera. A significant difference in fine specificity among HIV-1 infected individuals from Tanzania and the United States was observed for an immunodominant gp41 epitope. No significant differences in reactivity among asymptomatic vs. symptomatic HIV-1 infected individuals were detected for the selected HIV-1 gp160 epitopes defined by these peptides. The majority of sera from HIV-1 infected Tanzanians contained antibodies that recognized a peptide corresponding to the V3 region of gp120 from the HIV-1 MN isolate. These data suggest that regional isolates of HIV-1 may exist in Tanzania that differ from HIV-1 isolated in the United States. However, based on serology, HIV-1 isolates exhibiting sequences with HIV-1 MN V3 similarity may also be prevalent in Tanzania. The results of this study may be useful for the design of more effective AIDS diagnostic and therapeutic products for use worldwide.
ISSN:0146-6615
DOI:10.1002/jmv.1890370111